Pure autonomic failure
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| ICD-10 | ||
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| ICD-9 | ||
| OMIM | [1] | |
| DiseasesDB | 32777 | |
| MedlinePlus | [2] | |
| eMedicine | / | |
| MeSH | {{{MeshNumber}}} | |
Pure autonomic failure, also known as Bradbury-Eggleston syndrome or idiopathic orthostatic hypotension, is a form of dysautonomia that first occurs in middle age or later in life; men are affected more often than women. It is one of three diseases classified as primary autonomic failure.
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Symptoms
Edit
A degenerative disease of the autonomic nervous system, symptoms include dizziness and fainting (caused by orthostatic hypotension), visual disturbances and neck pain. Chest pain, fatigue and sexual dysfunction are less common symptoms that may also occur. Symptoms are worse when standing; sometimes one may relieve symptoms by lying down.
PathologyEdit
The pathology of pure autonomic failure is not yet completely understood. However, a loss of cells in the intermediolateral column of the spinal cord has been documented, as has a loss of catecholamine uptake and catecholamine fluorescence in sympathetic postganglionic neurons. In general, levels of catecholamines in these patients are very low while lying down, and do not increase much upon standing.
TreatmentEdit
Pharmacological methods of treatment include fludrocortisone, midodrine, somatostatin, erythropoietin, and other vasopressor agents. However, often a patient with pure autonomic failure can mitigate his or her symptoms with far less costly means. Compressing the legs and lower body, through crossing the legs, squatting, or the use of compression stockings can help. Also, ingesting more water than usual can increase blood pressure and relieve some symptoms.
EponymEdit
It is named for Samuel Bradbury and Cary Eggleston.[1][2]
ReferencesEdit
- ↑ Who Named It synd/2102
- ↑ S. Bradbury, C. Eggleston. Postural hypotension: A report of three cases. American Heart Journal, St. Louis, 1925, 1: 73-86.
External linksEdit
Autonomic nervous system disorders]], Dysautonomia, autonomic- neuropathy (G90, 337) | |
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| HSAN |
I · II · III/Familial dysautonomia · IV/Congenital insensitivity to pain with anhidrosis · V |
| Orthostatic intolerance |
Postural orthostatic tachycardia syndrome · Orthostatic hypotension |
| Other |
Horner's syndrome · Multiple system atrophy · Primary autonomic failure · Pure autonomic failure · Autonomic dysreflexia |
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