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Oxytocin evokes feelings of contentment, reductions in anxiety, and feelings of calmness and security around the mate.[1] Many studies have already shown a correlation of oxytocin with human bonding, increases in trust, and decreases in fear. One study confirmed that there is a positive correlation between oxytocin plasma levels and an anxiety scale measuring the adult romantic attachment.[2] This suggests that oxytocin may be important for the inhibition of brain regions that are associated with behavioral control, fear, and anxiety, thus allowing orgasm to occur.

  • Autism. Oxytocin may play a role in autism and may be an effective treatment for autism's repetitive and affiliative behaviors.[3] Oxytocin treatments also resulted in an increased retention of affective speech in adults with autism.[4] Two related studies in adults, in 2003 and 2007, found that oxytocin decreased repetitive behaviors and improved interpretation of emotions. More recently, intranasal administration of oxytocin was found to increase emotion recognition in children as young as 12 who are diagnosed with autism spectrum disorders [5] Oxytocin has also been implicated in the etiology of autism, with one report suggesting that autism is correlated with genomic deletion of the gene containing the oxytocin receptor gene (OXTR). Studies involving Caucasian and Finnish samples and Chinese Han families provide support for the relationship of OXTR with autism.[4][6] Autism may also be associated by an aberrant methylation of OXTR, as reported by Gregory and colleagues.[4] After treatment with inhaled oxytocin, autistic patients exhibit more appropriate social behavior.[7] While this research suggests some promise, further clinical trials of oxytocin are required to demonstrate potential benefit and side-effects in the treatment of autism. As such, researchers do not recommend use of oxytocin as a treatment for autism outside of clinical trials.
  • Increasing trust and reducing fear. In a risky investment game, experimental subjects given nasally administered oxytocin displayed "the highest level of trust" twice as often as the control group. Subjects who were told that they were interacting with a computer showed no such reaction, leading to the conclusion that oxytocin was not merely affecting risk-aversion.[8] Nasally administered oxytocin has also been reported to reduce fear, possibly by inhibiting the amygdala (which is thought to be responsible for fear responses).[9] Indeed, studies in rodents have shown that oxytocin can efficiently inhibit fear responses by activating an inhibitory circuit within the amygdala. Some researchers have argued that oxytocin has a general enhancing effect on all social emotions, since intranasal administration of oxytocin also increases envy and schadenfreude.[10]
  • Reducing trust of strangers, and increasing cultural and racial bias.[11]
  • Affecting generosity by increasing empathy during perspective taking. In a neuroeconomics experiment, intranasal oxytocin increased generosity in the Ultimatum Game by 80% but has no effect in the Dictator Game that measures altruism. Perspective-taking is not required in the Dictator Game, but the researchers in this experiment explicitly induced perspective-taking in the Ultimatum Game by not identifying to participants which role they would be in.[12] Serious methodological questions have arisen, however, with regards to the role of oxytocin in trust and generosity.[13]
  • Certain learning and memory functions are impaired by centrally administered oxytocin.[14] Also, systemic oxytocin administration can impair memory retrieval in certain aversive memory tasks.[15] Interestingly, oxytocin does seem to facilitate learning and memory specifically for social information. Healthy males administered intranasal oxytocin show improved memory for human faces, in particular happy faces.[16][17] They also show improved recognition for positive social cues over threatening social cues [18][19] and improved recognition of fear.[20]
  • Empathy in healthy males has been shown to be increased after intranasal oxytocin[21][22] This is most likely due to the effect of oxytocin in enhancing eye gaze.[23] There is some discussion about which aspect of empathy oxytocin might alter - for example, cognitive vs. emotional empathy.[24]

Actions within the brain Edit

Oxytocin secreted from the pituitary gland cannot re-enter the brain because of the blood-brain barrier. Instead, the behavioral effects of oxytocin are thought to reflect release from centrally projecting oxytocin neurons, different from those that project to the pituitary gland, or that are collaterals from them.[25] Oxytocin receptors are expressed by neurons in many parts of the brain and spinal cord, including the amygdala, ventromedial hypothalamus, septum, nucleus accumbens, and brainstem.

  • Sexual arousal. Oxytocin injected into the cerebrospinal fluid causes spontaneous erections in rats,[14] reflecting actions in the hypothalamus and spinal cord. Centrally administrated oxytocin receptor antagonists can prevent non-contact erections, which is a measure of sexual arousal. Studies using oxytocin antagonists in female rats provide data that oxytocin increases lordosis behavior, indicating an increase in sexual receptivity.[26]
  • The relationship between oxytocin and human sexual response is unclear. At least two non-controlled studies have found increases in plasma oxytocin at orgasm – in both men and women.[27][28] Plasma oxytocin levels are notably increased around the time of self-stimulated orgasm and are still higher than baseline when measured 5 minutes after self arousal.[27] The authors of one of these studies speculated that oxytocin's effects on muscle contractibility may facilitate sperm and egg transport.[27] In a study that measured oxytocin serum levels in women before and after sexual stimulation, the author suggests that oxytocin serves an important role in sexual arousal. This study found that genital tract stimulation resulted in increased oxytocin immediately after orgasm.[29] Another study that reports increases of oxytocin during sexual arousal states that it could be in response to nipple/areola, genital, and/or genital tract stimulation as confirmed in other mammals.[30] Murphy et al. (1987), studying men, found that oxytocin levels were raised throughout sexual arousal and there was no acute increase at orgasm.[31] A more recent study of men found an increase in plasma oxytocin immediately after orgasm, but only in a portion of their sample that did not reach statistical significance. The authors noted that these changes "may simply reflect contractile properties on reproductive tissue."[32]

  • Bonding. In the Prairie Vole, oxytocin released into the brain of the female during sexual activity is important for forming a monogamous pair bond with her sexual partner. Vasopressin appears to have a similar effect in males.[33] Oxytocin has a role in social behaviors in many species, and so it seems likely that it also does in humans. In 2003, a study showed that in both humans and dogs oxytocin levels in the blood rose after five to twenty-four minutes of a petting session. It is possible that this plays a role in the emotional bonding between humans and dogs.[34]
  • Maternal behavior. Female rats given oxytocin antagonists after giving birth do not exhibit typical maternal behavior.[35] By contrast, virgin female sheep show maternal behavior toward foreign lambs upon cerebrospinal fluid infusion of oxytocin, which they would not do otherwise.[36] Oxytocin is involved in the initiation of maternal behavior, not its maintenance; for example, it is higher in mothers after they interact with unfamiliar children rather than their own.[37]
  • According to some studies in animals, oxytocin inhibits the development of tolerance to various addictive drugs (opiates, cocaine, alcohol) and reduces withdrawal symptoms.[38]
  • Preparing fetal neurons for delivery. Crossing the placenta, maternal oxytocin reaches the fetal brain and induces a switch in the action of neurotransmitter GABA from excitatory to inhibitory on fetal cortical neurons. This silences the fetal brain for the period of delivery and reduces its vulnerability to hypoxic damage.[39]
  • MDMA (ecstasy) may increase feelings of love, empathy, and connection to others by stimulating oxytocin activity via activation of serotonin 5-HT1A receptors, if initial studies in animals apply to humans.[40] The anxiolytic Buspar (buspirone) also appears to produce some or all of its effect via 5-HT1A receptor-induced oxytocin stimulation.[41][42]

See also=Edit


  1. Meyer, Dixie (2007). Selective Serotonin Reuptake Inhibitors and Their Effects on Relationship Satisfaction. The Family Journal 15 (4): 392–397.
  2. Marazziti D (2006). A relationship between oxytocin and anxiety of romantic attachment. Clinical Practice and Epidemiology in Mental Health 2: 28.
  3. Bartz JA, Hollander E (2008). Oxytocin and experimental therapeutics in autism spectrum disorders. Progress in Brain Research 170: 451–62.
  4. 4.0 4.1 4.2 Jacob S, Brune CW, Carter CS, Leventhal BL, Lord C, Cook EH (April 2007). Association of the Oxytocin Receptor Gene (OXTR) in Caucasian Children and Adolescents with Autism. Neuroscience Letters 417 (1): 6–9.
  5. Guastella AJ, Einfeld EL, Gray, K, Rinehart N, Tonge B, Lambert TJ, Hickie IB (April 2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry 67 (7): 692–4.
  6. Wermter AK, Kamp-Becker I, Hesse P, Schulte-Körne G, Strauch K, Remschmidt H (September 2009). Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 153B (2): 629–39.
  7. Andaria E, Duhamela J-R, Zallab T, Herbrechtb E, Leboyerb M, Sirigu A (2010). Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc. Natl. Acad. Sci. U.S.A. 107 (9): 4389–94.
  8. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (June 2005). Oxytocin increases trust in humans. Nature 435 (7042): 673–6.
  9. Kirsch P (December 2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. The Journal of Neuroscience 25 (49): 11489–93.
  10. Shamay-Tsoory SG, Fischer M, Dvash J, Harari H, Perach-Bloom N, Levkovitz Y (November 2009). Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biological Psychiatry 66 (9): 864–70.
  11. Ed Yong. No love for outsiders – oxytocin boosts favouritism towards our own ethnic or cultural group. Discover Magazine. Kalmbach Publishing Co.. URL accessed on 21 Feb 2011.
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  25. Cite error: Invalid <ref> tag; no text was provided for refs named Ross
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