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Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
- Main article: Aphasia
|Primary progressive aphasia|
|Classification and external resources|
The classification of Primary Progressive Aphasias, has a clinical and pathological overlap of Frontotemporal Lobar Degeneration (FTLD) spectrum of disorders and Alzheimer pathology. In the classical Mesulam criteria for primary progressive aphasia there are 2 variants: a non-fluent type Progressive Nonfluent Aphasia (PNFA) and a fluent type Semantic Dementia (SD). The third variant of primary progressive aphasia Logopenic Progressive Aphasia (LPA) is an atypical form of Alzheimer's. And these are the three classifications of primary progressive aphasia.
The following diagnosis criteria were defined by Mesulam 
- Gradual impairment of word-processing, object naming, syntax and word-processing
- Premorbid language function is usually intact
- Acalculia - inability to perform simple mathematical calculations
- Ideomotor Apraxia - loss of the ability to execute or carry out learned purposeful movements
There are no known environmental risk factors for the progressive aphasias. However, one observational study has recently suggested that vasectomy could be a risk factor for PPA in men. These results have yet to be replicated elsewhere.
PPA is not considered a hereditary disease. However, relatives of a person with any form of frontotemporal lobar degeneration, including PPA, are at slightly greater risk of developing PPA or another form of the condition.
There is no approved treatment. Rapid and sustained improvement in speech and dementia in a patient with primary progressive aphasia utilizing perispinal etanercept off-label, an anti-TNF treatment strategy also used for Alzheimer's, was recently reported. A video depicting the patient's improvement was published in conjunction with the print article. These findings have not been independently replicated, and remain controversial.
- ↑ 1.0 1.1 Mesulam MM (April 2001). Primary progressive aphasia. Ann. Neurol. 49 (4): 425–32.
- ↑ Mesulam M (1982). Slowly progressive aphasia without generalized dementia. Ann Neurol. 11 (6): 592–8.
- ↑ Adlam AL, Patterson K, Rogers TT, et al. (Nov 2006). Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?. Brain 129 (Pt 11): 3066–80.
- ↑ Gorno-Tempini ML, Dronkers NF, Rankin KP, et al. (Mar 2004). Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 55 (3): 335–46.
- ↑ Gorno-Tempini ML, Hillis AE, Weintraub S, et al. (March 2011). Classification of primary progressive aphasia and its variants. Neurology 76 (11): 1006–14.
- ↑ Bonner MF, Ash S, Grossman M (November 2010). The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants. Curr Neurol Neurosci Rep 10 (6): 484–90.
- ↑ Harciarek M, Kertesz A (September 2011). Primary progressive aphasias and their contribution to the contemporary knowledge about the brain-language relationship. Neuropsychol Rev 21 (3): 271–87.
- ↑ Mesulam MM: Primary progressive aphasia—a language-based dementia. N Engl J Med 2003, 349:1535–1542
- ↑ Weintraub S, Fahey C, Johnson N, et al. (December 2006). "Vasectomy in men with primary progressive aphasia". Cogn Behav Neurol 19 (4): 190–3. DOI:10.1097/01.wnn.0000213923.48632.ab . PMID 17159614.
- ↑ Goldman JS, Farmer JM, Wood EM, et al. (Dec 2005). Comparison of family histories in FTLD subtypes and related tauopathies. Neurology 65 (11): 1817–9.
- ↑ Tobinick E (2008). Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanism. Medscape Journal of Medicine 10 (6): 135.
Further reading Edit
- Amici S, Ogar J, Brambati SM, et al. (Dec 2007). Performance in specific language tasks correlates with regional volume changes in progressive aphasia. Cognitive & Behavioral Neurology 20 (4): 203–11.
- Gliebus G (March 2010). Primary progressive aphasia: clinical, imaging, and neuropathological findings. Am J Alzheimers Dis Other Demen 25 (2): 125–7.
- Henry ML, Gorno-Tempini ML (December 2010). The logopenic variant of primary progressive aphasia. Curr. Opin. Neurol. 23 (6): 633–7.
- Reilly J, Rodriguez AD, Lamy M, Neils-Strunjas J (2010). Cognition, language, and clinical pathological features of non-Alzheimer's dementias: an overview. J Commun Disord 43 (5): 438–52.
- Rohrer JD, Knight WD, Warren JE, Fox NC, Rossor MN, Warren JD (January 2008). Word-finding difficulty: a clinical analysis of the progressive aphasias. Brain 131 (Pt 1): 8–38.
- FAQ on PPA from IMPPACT, the International PPA Connection
- PPA information from the UCSF Memory and Aging Center
- Northwestern Cognitive Neurology and Alzheimer's Disease Center
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