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'''Presenile dementia''' is specifically a [[dementia]] that starts before the age of 65 in contrast to [[senile dementia]] in the aged.
 
'''Presenile dementia''' is specifically a [[dementia]] that starts before the age of 65 in contrast to [[senile dementia]] in the aged.
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The first symptoms are often mistaken as related to [[aging]] or [[Stress (biological)|stress]].<ref name="pmid17222085"/> Detailed [[neuropsychology|neuropsychological]] testing can reveal mild cognitive difficulties up to eight years before a person fulfills the clinical criteria for [[diagnosis]] of AD.<ref name="pmid15324363">{{cite journal
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|author=Bäckman L, Jones S, Berger AK, Laukka EJ, Small BJ
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|title=Multiple cognitive deficits during the transition to Alzheimer's disease
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|journal=J Intern Med
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|volume=256
  +
|issue=3
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|pages=195–204
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|year=2004
  +
|month=Sep
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|pmid=15324363
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|doi=10.1111/j.1365-2796.2004.01386.x
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}}</ref> These early symptoms can affect the most complex [[Activities of daily living|daily living activities]].<ref>{{cite journal
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|author= Nygård L
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|title=Instrumental activities of daily living: a stepping-stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment?
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|journal=Acta Neurol Scand
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|volume=Suppl
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|issue=179
  +
|pages=42–6
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|year=2003
  +
|month=
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|pmid=12603250
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|doi= 10.1034/j.1600-0404.107.s179.8.x
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}}</ref> The most noticeable deficit is memory loss, which shows up as difficulty in remembering recently learned facts and inability to acquire new information.<ref name="pmid15324363"/><ref name="pmid12603249">{{cite journal
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|author=Arnáiz E, Almkvist O
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|title=Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease
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|journal=Acta Neurol. Scand., Suppl.
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|volume=179
  +
|pages=34–41
  +
|year=2003
  +
|pmid=12603249
  +
|doi=10.1034/j.1600-0404.107.s179.7.x
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|accessdate=2008-06-12
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}}</ref>
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Subtle problems with the [[executive functions]] of [[attention|attentiveness]], [[planning]], [[flexibility]], and [[abstraction|abstract thinking]], or impairments in [[semantic memory]] (memory of meanings, and concept relationships), can also be symptomatic of the early stages of AD.<ref name="pmid15324363"/> [[Apathy]] can be observed at this stage, and remains the most persistent [[neuropsychiatry|neuropsychiatric]] symptom throughout the course of the disease.<ref>{{cite journal
  +
|author=Landes AM, Sperry SD, Strauss ME, Geldmacher DS
  +
|title=Apathy in Alzheimer's disease
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|journal=J Am Geriatr Soc
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|volume=49
  +
|issue=12
  +
|pages=1700–7
  +
|year=2001
  +
|month=Dec
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|pmid=11844006
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|doi=10.1046/j.1532-5415.2001.49282.x
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}}</ref> The preclinical stage of the disease has also been termed [[mild cognitive impairment]],<ref name="pmid12603249"/> but whether this term corresponds to a different diagnostic stage or identifies the first step of AD is a matter of dispute.<ref name="pmid17279076">
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{{cite journal
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|author=Petersen RC
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|title=The current status of mild cognitive impairment—what do we tell our patients?
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|journal=Nat Clin Pract Neurol
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|volume=3
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|issue=2
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|pages=60–1
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|year=2007
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|month=February
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|pmid=17279076
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|doi=10.1038/ncpneuro0402
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}}</ref>
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==See also==
 
==See also==
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==References & Bibliography==
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==References==
<References/>
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{{Reflist|2}}
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==Further reading==
 
==Key texts==
 
==Key texts==
 
===Books===
 
===Books===

Latest revision as of 21:38, December 8, 2009

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Presenile dementia is specifically a dementia that starts before the age of 65 in contrast to senile dementia in the aged.

The first symptoms are often mistaken as related to aging or stress.[1] Detailed neuropsychological testing can reveal mild cognitive difficulties up to eight years before a person fulfills the clinical criteria for diagnosis of AD.[2] These early symptoms can affect the most complex daily living activities.[3] The most noticeable deficit is memory loss, which shows up as difficulty in remembering recently learned facts and inability to acquire new information.[2][4]

Subtle problems with the executive functions of attentiveness, planning, flexibility, and abstract thinking, or impairments in semantic memory (memory of meanings, and concept relationships), can also be symptomatic of the early stages of AD.[2] Apathy can be observed at this stage, and remains the most persistent neuropsychiatric symptom throughout the course of the disease.[5] The preclinical stage of the disease has also been termed mild cognitive impairment,[4] but whether this term corresponds to a different diagnostic stage or identifies the first step of AD is a matter of dispute.[6]


See alsoEdit


ReferencesEdit

  1. Cite error: Invalid <ref> tag; no text was provided for refs named pmid17222085
  2. 2.0 2.1 2.2 Bäckman L, Jones S, Berger AK, Laukka EJ, Small BJ (Sep 2004). Multiple cognitive deficits during the transition to Alzheimer's disease. J Intern Med 256 (3): 195–204.
  3. Nygård L (2003). Instrumental activities of daily living: a stepping-stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment?. Acta Neurol Scand Suppl (179): 42–6.
  4. 4.0 4.1 Arnáiz E, Almkvist O (2003). Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease. Acta Neurol. Scand., Suppl. 179: 34–41.
  5. Landes AM, Sperry SD, Strauss ME, Geldmacher DS (Dec 2001). Apathy in Alzheimer's disease. J Am Geriatr Soc 49 (12): 1700–7.
  6. Petersen RC (February 2007). The current status of mild cognitive impairment—what do we tell our patients?. Nat Clin Pract Neurol 3 (2): 60–1.

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