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|Nerve: Preganglionic fibers|
|Autonomic nervous system innervation, showing the sympathetic and parasympathetic (craniosacral) systems, in red and blue, respectively|
|Gray's||subject #185 758|
All preganglionic fibers, whether they are in the sympathetic division or in the parasympathetic division, are both cholinergic (that is, these fibers use acetylcholine as their neurotransmitter) and either unmyelinated or myelinated.
Sympathetic preganglionic fibers tend to be shorter than parasympathetic preganglionic fibers because sympathetic ganglia are often closer to the spinal cord than are the parasympathetic ganglia. Another major difference between the two ANS systems is divergence. Whereas in the parasympathetic division there is a divergence factor of roughly 1:4, in the sympathetic division there can be a divergence of up to 1:20. This is due to the number of synapses formed by the preganglionic fibers with ganglionic neurons.
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