Wikia

A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.

Some examples include:

Diazoxide^[1] vasodilator used for hypertension, smooth muscle relaxing activity
Minoxidil^[2] vasodilator used for hypertension, also used to treat hair loss
Nicorandil^[3] vasodilator used to treat angina
Pinacidil^[4]
Retigabine^[5]^[6], an anticonvulsant
Flupirtine, analgesic with muscle relaxant and anticonvulsant properties

References Edit

↑ Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005). Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener. Circulation 112 (9 Suppl): I219–23.
↑ Wang T (February 2003). The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle. J. Pharmacol. Exp. Ther. 304 (2): 833–40.
↑ Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008). Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction. Biol. Pharm. Bull. 31 (11): 2079–82.
↑ Stojnic N, Gojkovic-Bukarica L, Peric M, et al. (June 2007). Potassium channel opener pinacidil induces relaxation of the isolated human radial artery. J. Pharmacol. Sci. 104 (2): 122–9.
↑ Rundfeldt C (October 1997). The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells. European Journal of Pharmacology 336 (2–3): 243–9.
↑ Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. Molecular Pharmacology 58 (2): 253–62.