Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

Post-Tetanic Potentiation (PTP) is a form of synaptic plasticity which is short-lived and results in increased frequency of miniature excitatory postsynaptic potentials (mEPSPs) or currents (mEPSCs) with no effect on amplitude in the spontaneous postsynaptic potential.[1] It usually lasts in the range of several minutes (shorter potentiations are usually referred to as 'augmentations'). PTPs are observed when synapses are stimulated with repetitive (tetanic) pulses, by means of prolonged trains of stimuli applied at high frequencies (10 Hz to 200 Hz stimuli applied for .2 seconds to 5 seconds).[2]

PTPs are thought to result primarily from the buildup of calcium concentration in the axon terminal of the presynaptic neuron during the stimulus train.[2]

In some cases, depression can be observed instead of potentiation following the tetanic stimulus.[2]


  1. [1] Jian-Xin Bao, Eric R. Kandel, Robert D. Hawkins. "Involvement of Pre- and Postsynaptic Mechanisms in Posttetanic Potentiation at Aplysia Synapses ." Science Magazine Online. Science 14 February 1997: Vol. 275. no. 5302, pp. 969 - 973. DOI:10.1126/science.275.5302.969 . April 2009. <>
  2. 2.0 2.1 2.2 Malenka, Robert C.. Neuropsychopharmacology: The Fifth Generation of Progress, 147–154.

This page uses Creative Commons Licensed content from Wikipedia (view authors).

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.