Wikia

Psychology Wiki

Pituitary-adrenal axis

Talk0
34,139pages on
this wiki

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


Merge-arrow
It has been suggested that this article or section be merged into Hypothalamic-pituitary-adrenal axis. (Discuss)

In medicine and physiology, the Pituitary-adrenal axis, also termed the Hypothalamus-pituitary-adrenal axis, is the hormonal system of which the effector organ is the adrenal cortex.

Adrenal and pituitary Edit

The adrenal cortex produces cortisol in response to stimulation by corticotropin (or: ACTH, adrenocorticotropic hormone). The pituitary gland, specifically the corticotroph cells, sense the blood levels of cortisol. If the levels are too low, more ACTH is secreted and the cortical activity is increased.

The hypothalamus Edit

The hypothalamus controls the rate at which the corticotroph cells respond. In acute illness, higher cortisol levels are needed (see adrenal insufficiency). This is achieved by the hypothalamus secreting higher levels of CRH (corticotropin releasing hormone) into the portal system. This stimulates the corticotroph cells to a higher set point, leading to increased ACTH and cortisol levels.

Regulation at hypothalamus level Edit

Now what controls the hypothalamus? This can be stress of emotional or physical nature; the CRH pulse rate (it is secreted in pulses; the rate determines its function) is increased in response to systemic inflammation, namely IL-1, IL-6 and TNF alpha.

See also Edit

This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki