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*[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=bnchm.section.1181 Basic Neurochemistry: GABA Receptor Physiology and Pharmacology]
 
*[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=bnchm.section.1181 Basic Neurochemistry: GABA Receptor Physiology and Pharmacology]
   
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[[Category:Analeptic drugs]]
 
[[Category:GABA antagonists]]
 
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Latest revision as of 14:57, November 30, 2009

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Picrotoxin chemical structure
Picrotoxin


IUPAC name
CAS number
124-87-8
ATC code

[[ATC_code_|]][1]

PubChem
5360688
DrugBank
APRD00269
Chemical formula {{{chemical_formula}}}
Molecular weight 602.583 g/mol
Bioavailability
Metabolism
Elimination half-life
Excretion
Pregnancy category
Legal status
Routes of administration


Picrotoxin, also known as cocculin, is a poisonous crystalline plant alkaloid, first isolated by Boullay in 1812.

Found primarily in Cocculus indicus and Anamirta cocculus, it has a strong physiological action. It acts as a non-competitive antagonist of GABA A receptors. As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has a stimulative effect.

Chemical structure Edit

Picrotoxin (C30H34O13) consists of two substances, picrotoxinin (C15H1606) and picrotin (C15H1807).

ReferencesEdit

  • L. Dupont, O. Dideberg, J. Lamotte-Brasseur et L. Angenot (1976). Structure cristalline et moléculaire de la picrotoxine, C15H16O6.C15H18O7. Acta Cryst. B32: 2987–2993. (in French)

External linksEdit


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