Picrotoxin
From Psychology Wiki
Community portal · Tasks to do · News · Help
Clinical · Educational · Ind&Org · Other fields · Professional · Transpersonal · World
Assessment |
Biopsychology |
Comparative |
Cognitive |
Developmental |
Language
Personality |
Philosophy |
Research Methods |
Social |
Statistics
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology
|
File:Picrotoxin 3D sticks.png | |
| IUPAC name | |
| CAS number 124-87-8 | ATC code [[ATC_code_|]][1] |
| PubChem 5360688 | DrugBank APRD00269 |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 602.583 g/mol |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Pregnancy category | |
| Legal status | |
| Routes of administration | |
Picrotoxin, also known as cocculin, is a poisonous crystalline plant alkaloid, first isolated by Boullay in 1812.
Found primarily in Cocculus indicus and Anamirta cocculus, it has a strong physiological action. It acts as a non-competitive antagonist of GABA A receptors. As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has a stimulative effect.
[edit] Chemical structure
Picrotoxin (C30H34O13) consists of two substances, picrotoxinin (C15H1606) and picrotin (C15H1807).
[edit] References
- L. Dupont, O. Dideberg, J. Lamotte-Brasseur et L. Angenot (1976). Structure cristalline et moléculaire de la picrotoxine, C15H16O6.C15H18O7. Acta Cryst. B32: 2987–2993. (in French)
[edit] External links
- Ehrenberger K, Benkoe E, Felix D (1982). Suppressive action of picrotoxin, a GABA antagonist, on labyrinthine spontaneous nystagmus and vertigo in man. Acta Otolaryngol. 93 (3-4): 269–73.
- Basic Neurochemistry: GABA Receptor Physiology and Pharmacology
| This page uses content from the English-language version of Wikipedia. The original article was at Picrotoxin. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
