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In physiology, tolerance occurs when an organism builds up a resistance to the effects of a substance after repeated exposure. This can occur with environmental substances such as salt or pesticides. It is also commonly encountered in pharmacology (see drug tolerance), when a subject's reaction to a drug (such as a painkiller or intoxicant) decreases so that larger doses are required to achieve the same effect.

See also Edit

• Desensitization
• Drug tolerance
• Tachyphylaxis
• Mithridatization

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