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Parkinson-plus syndromes are a group of diseases featuring the classical features of Parkinson's disease (tremor; rigidity; akinesia/bradykinesia; postural instability) with additional features that distinguish them from simple idiopathic Parkinson's disease.
The Parkinson-plus syndromes and their additional features are:
- Multiple system atrophy (MSA)
- Progressive supranuclear palsy (PSP)
- failure of voluntary vertical eye movements
- early dementia
- Corticobasal degeneration (CBD)
- Dementia with Lewy bodies (DLB)
- early cognitive impairment
- Olivopontocerebellar atrophy (OPCA)
It is said by neurologists that patients presenting with falls early in the course of a Parkinsonian illness are more likely to have a Parkinson-plus syndrome than idiopathic Parkinson's disease.
The Parkinson-plus syndromes are usually more rapidly progressive and less likely to respond to anti-parkinsonian medication than Parkinson's disease. However, the additional features of the diseases may respond to medications not used in Parkinson's disease.
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