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Pargyline

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Pargyline chemical structure
Pargyline

2-[benzyl(methyl)amino]acetonitrile
IUPAC name
CAS number
555-57-7
ATC code

C02KC01 .

PubChem
4688
DrugBank
[1]
Chemical formula {{{chemical_formula}}}
Molecular weight 159.23 g/mol
Bioavailability
Metabolism
Elimination half-life
Excretion
Pregnancy category
Legal status
Routes of administration


Pargyline is a monoamine oxidase B (MAO-B) inhibitor. [1]

It has antihypertensive effects.[2]

PharmacologyEdit

It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis.[3]

ReferencesEdit

  1. Murphy DL, Karoum F, Pickar D, et al (1998). Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline). J. Neural Transm. Suppl. 52: 39–48.
  2. Fuentes JA, Ordaz A, Neff NH (July 1979). Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats. Eur. J. Pharmacol. 57 (1): 21–7.
  3. Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006
Template:Antihypertensives and diuretics


Antidepressants (ATC N06A) edit
Monoamine oxidase inhibitors (MAOI) Harmaline, Iproclozide, Iproniazid, Isocarboxazid, Nialamide, Phenelzine, Selegiline, Toloxatone, Tranylcypromine
Reversible inhibitor of monoamine oxidase A (RIMA) Brofaromine, Moclobemide
Dopamine reuptake inhibitor (DARI) Amineptine, Phenmetrazine, Vanoxerine, Modafinil
Norepinephrine-dopamine reuptake inhibitors Bupropion
Norepinephrine reuptake inhibitor (NRI) or (NARI) Atomoxetine, Maprotiline, Reboxetine, Viloxazine
Serotonin-norepinephrine reuptake inhibitor (SNRI) Duloxetine, Milnacipran, Venlafaxine
Selective serotonin reuptake inhibitor (SSRI) Alaproclate, Etoperidone, Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine
Selective serotonin reuptake enhancer (SSRE) Tianeptine
Tricyclic antidepressants (TCA) Amitriptyline, Amoxapine, Butriptyline, Clomipramine, Desipramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Lofepramine, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine
Tetracyclic antidepressants Maprotiline, Mianserin, Nefazodone, Trazodone
Noradrenergic and specific serotonergic antidepressant (NaSSA) Mirtazapine
This page uses Creative Commons Licensed content from [[Wikipedia:Pargyline Wikipedia]] (view authors).

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