Wikia

Psychology Wiki

Paraventricular nucleus

Talk0
34,141pages on
this wiki
Revision as of 11:25, November 16, 2006 by Lifeartist (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


The paraventricular nucleus (PVN) is an aggregation of neurons in the hypothalamus, adjacent to the third ventricle. The PVN is highly vascularised, but is inside the blood-brain barrier, although the neuroendocrine neurons in this nucleus project to sites (the median eminence and the posterior pituitary) that lack a blood-brain barrier. The PVN contains magnocellular neurosecretory cells whose axons extend into the posterior pituitary, parvocellular neurosecretory cells that project to the median eminence, and several populations of peptide-containing cells that project to many different brain regions.

Magnocellular neurosecretory neurons in the PVNEdit

The magnocellular cells in the PVN produce oxytocin and vasopressin. These peptide hormones are packaged in large dense-core vesicles, which are transported down the axons and released from neurosecretory nerve terminals in the posterior pituitary gland. Similar magnocellular neurons are found in the supraoptic nucleus.

Parvocellular neurosecretory neuronsEdit

The parvocellular neurosecretory neurons of the PVN project axons to the median eminence, at the base of the brain. At the median eminence, the neurosecretory nerve terminals release peptides into the blood vessels of the hypothalamo-pituitary portal system. These vessels carry the peptides to the anterior pituitary gland, where they regulate hormone secretion into the systemic circulation. The parvocellular neurosecretory cells include:

  • cells that make CRF, which regulates ACTH secretion from the anterior pituitary gland,
  • cells that make vasopressin: vasopressin released from these neurons also regulates ACTH secretion; vasopressin and CRF act synergistically to stimulate ACTH secretion.
  • cells that make TRH, which regulates TSH secretion.

Centrally-projecting neuronsEdit

As well as neuroendocrine neurons, the PVN contains interneurons and populations of neurons that project centrally (i.e. to other brain regions). The centrally-projecting neurons include:

  • parvocellular oxtocin cells that project mainly to the brainstem and spinal cord. The oxytocin cells that project to the brainstem are involved in gastric reflexes, those that project to the spinal cord are involved in erectile mechanisms.
  • parvocellular vasopressin cells that project to many areas of the hypothalamus and limbic system, as well as to the brainstem and spinal cord. Thes neurons are involved in blood pressure regulation and thermoregulation.
  • parvocellular CRF neurons that are thought to be involved in stress-associated behaviors

Afferent inputs to the PVNEdit

The PVN receives afferent inputs from many brain regions. Amongst these, inputs from neurons in structures adjacent to the anterior wall of the third ventricle ("AV3V region") carry information about the electrolyte composition of the blood, and about circulating concentrations of hormones such as angiotensin and relaxin to regulate the magnocellular neurons. Inputs from the brainstem nucleus of the solitary tract and the ventrolateral medulla carry information from the heart and stomach. Inputs from the hippocampus to the CRF neurones are important regulators of stress responses. Inputs from the NPY neurons in the arcuate nucleus co-ordinate metabolic regulation via TRH secretion with regulation of energy intake.


External linksEdit

Telencephalon (cerebrum, cerebral cortex, cerebral hemispheres) - edit

primary sulci/fissures: medial longitudinal, lateral, central, parietoöccipital, calcarine, cingulate

frontal lobe: precentral gyrus (primary motor cortex, 4), precentral sulcus, superior frontal gyrus (6, 8), middle frontal gyrus (46), inferior frontal gyrus (Broca's area, 44-pars opercularis, 45-pars triangularis), prefrontal cortex (orbitofrontal cortex, 9, 10, 11, 12, 47)

parietal lobe: postcentral sulcus, postcentral gyrus (1, 2, 3, 43), superior parietal lobule (5), inferior parietal lobule (39-angular gyrus, 40), precuneus (7), intraparietal sulcus

occipital lobe: primary visual cortex (17), cuneus, lingual gyrus, 18, 19 (18 and 19 span whole lobe)

temporal lobe: transverse temporal gyrus (41-42-primary auditory cortex), superior temporal gyrus (38, 22-Wernicke's area), middle temporal gyrus (21), inferior temporal gyrus (20), fusiform gyrus (36, 37)

limbic lobe/fornicate gyrus: cingulate cortex/cingulate gyrus, anterior cingulate (24, 32, 33), posterior cingulate (23, 31),
isthmus (26, 29, 30), parahippocampal gyrus (piriform cortex, 25, 27, 35), entorhinal cortex (28, 34)

subcortical/insular cortex: rhinencephalon, olfactory bulb, corpus callosum, lateral ventricles, septum pellucidum, ependyma, internal capsule, corona radiata, external capsule

hippocampal formation: dentate gyrus, hippocampus, subiculum

basal ganglia: striatum (caudate nucleus, putamen), lentiform nucleus (putamen, globus pallidus), claustrum, extreme capsule, amygdala, nucleus accumbens

Some categorizations are approximations, and some Brodmann areas span gyri.

This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki