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Parathyroid hormone receptor

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parathyroid hormone receptor 1
Symbol(s): PTHR1 PTHR
Locus: 3 p22 -p21.1
EC number [1]
EntrezGene 5745
OMIM 168468
RefSeq NM_000316
UniProt Q03431
parathyroid hormone receptor 2
Symbol(s): PTHR2
Locus: 2 q33
EC number [2]
EntrezGene 5746
OMIM 601469
RefSeq NM_005048
UniProt P49190

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors are members of the 7 transmembrane G protein-coupled family of receptors.[1]


  1. Jüppner H (1994). Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors. Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8.
  2. Mannstadt M, Jüppner H, Gardella TJ (1999). Receptors for PTH and PTHrP: their biological importance and functional properties. Am. J. Physiol. 277 (5 Pt 2): F665–75.
  3. Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells. Mol. Endocrinol. 10 (5): 566–74.
  4. Usdin TB, Bonner TI, Hoare SR (2002). The parathyroid hormone 2 (PTH2) receptor. Recept. Channels 8 (3-4): 211–8.

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