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Parachlorophenylalanine

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Parachlorophenylalanine chemical structure
Parachlorophenylalanine

2-amino-3-(4-chlorophenyl)propanoic acid
IUPAC name
CAS number
7424-00-2
ATC code

[[ATC_code_|]][1]

PubChem
4652
DrugBank
[2]
Chemical formula {{{chemical_formula}}}
Molecular weight 199.634 g/mol
Bioavailability
Metabolism
Elimination half-life
Excretion
Pregnancy category
Legal status
Routes of administration



Parachlorophenylalanine (p-Chlorophenylalanine, PCPA) aka Fenclonine is a synthetic amino acid which acts as a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin.[1] Fenclonine consequently depletes serotonin in the body and reduces its actions, acting as an indirect serotonin antagonist. It is used in scientific research to investigate the effects of serotonin depletion on behaviour.[2]


See also

References

  1. Jéquier E, Lovenberg W, Sjoerdsma A. Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin. Molecular Pharmacology. 1967 May;3(3):274-8. PMID 6037686
  2. O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berlin). 2007 Jun;192(3):357-71. PMID 17318507

Template:Serotonin antagonists

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