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Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
|Chemical name||Oxobutanedioic acid|
|Other names|| Oxaloacetic acid|
|Molecular mass||132.07 g/mol|
|Melting point||161 °C|
|pKa value|| 2.22|
| Standard enthalpy|
of formation ΔfH°solid
| Standard enthalpy|
of combustion ΔcH°solid
|Disclaimer and references|
Oxaloacetic acid, also known as oxosuccinic acid or oxalacetic acid, is a four-carbon dicarboxylic acid appearing as an intermediate of the citric acid cycle and gluconeogenesis. In vivo, oxaloacetate (the ionised form of oxaloacetic acid) is formed by the oxidation of L-malate, catalysed by malate dehydrogenase, and reacts with Acetyl-CoA to form citrate, catalysed by citrate synthase. It is also formed in the mesophyll of plants by the condensation of CO2 with phosphoenolpyruvate, catalysed by oxaloacetate decarboxylase. It can be formed from pyruvate as an anaplerotic reaction.
The enol forms of oxaloacetic acid are particularly stable, so much so that the two isomers have different melting points (152°C cis, 184°C trans). The enol proton has a pKa value of 13.02. The enzyme fumarase A from E. coli catalyses the conversion between the keto and enol forms.
Oxaloacetic acid is unstable in solution, decomposing to pyruvic acid by decarboxylation over a period of hours (room temperature) or days (0°C). Refrigerator storage of the solid is recommended for long periods.
Citric Acid Cycle Metabolic Pathway
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