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Orexin receptor

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hypocretin (orexin) receptor 1
Symbol(s): HCRTR1
Locus: 1 p33
EC number [1]
EntrezGene 3061
OMIM 602392
RefSeq NM_001525
UniProt O43613
hypocretin (orexin) receptor 2
Symbol(s): HCRTR2
Locus: 6 p11 -q11
EC number [2]
EntrezGene 3062
OMIM 602393
RefSeq NM_001526
UniProt O43614

The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide hormone orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2).[1]


  1. Spinazzi R, Andreis PG, Rossi GP, Nussdorfer GG (2006). Orexins in the regulation of the hypothalamic-pituitary-adrenal axis. Pharmacol. Rev. 58 (1): 46–57.

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