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{{BioPsy}}
 
{{BioPsy}}
The '''Mendelian Inheritance in Man''' project is a database that catalogues all the known [diseases with a [[genetic disorder|genetic component]], and - when possible - links them to the relevant [[genes]] in the [[human genome]]. It is available as a book titled ''[[Mendelian inheritance|Mendelian Inheritance]] in Man'' (MIM), which is currently in its 12th edition.
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'''Online Mendelian Inheritance in Man''' ('''OMIM''') is a [[database]] that catalogues all the known [[disease]]s with a [[genetic disorder|genetic component]], and when possible links them to the relevant [[genes]] in the [[human genome]] and provides references for further research and tools for genomic analysis of a catalogued gene.<ref name="Hamosh">{{cite pmid|15608251}}</ref> OMIM is one of the databases housed in the U.S. [[National Center for Biotechnology Information]] (NCBI) and included in its search menus.<ref name="urlNational Center for Biotechnology Information">{{cite web |url=http://www.ncbi.nlm.nih.gov/ |title=National Center for Biotechnology Information |format= |work= |accessdate=2011-04-20}}</ref>
   
The online version is called '''Online Mendelian Inheritance in Man''' (OMIM), which can be accessed with the [[Entrez]] database searcher of the [[National Library of Medicine]].
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== Versions ==
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Mendelian Inheritance in Man was started in the early 1960s<ref name="urlOMIM Help">{{cite web |url=http://www.omim.org/help/about |title=OMIM Help |format= |work= |accessdate=2011-04-20}}</ref> and is available as a book currently in its 12th edition.<ref>{{cite book | last = McKusick | first = VA | title = Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders | location = Baltimore, Maryland | publisher = [[Johns Hopkins University Press]] | year = 1998 | isbn = 0-8018-5742-2}}</ref> The [[online]] version, OMIM, has been available since 1987,<ref>{{cite pmid|8423603}}</ref> moved to the World Wide Web by NCBI in 1995,<ref name="urlOMIM Help" /> and in 2004 contained more than 15,000 records.<ref name="Hamosh"/>
   
OMIM&trade; and Online Mendelian Inheritance in Man&trade; are trademarks of the [[Johns Hopkins University]].
 
   
 
==Collection process==
 
==Collection process==
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==The MIM code==
 
==The MIM code==
 
Every disease and [[gene]] is assigned a six digit number of which the first number classifies the method of inheritance.
 
Every disease and [[gene]] is assigned a six digit number of which the first number classifies the method of inheritance.
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If the initial digit is 1, the trait is deemed [[autosomal dominant]]; if 2, [[autosomal recessive]]; if 3, [[X-linked]]. Wherever a trait defined in this dictionary has a MIM number, the number from the 12th edition of MIM, is given in square brackets with or without an asterisk (asterisks indicate that the mode of inheritance is known; a number symbol (#) before an entry number means that the phenotype can be caused by mutation in any of two or more genes) as appropriate e.g., [[Pelizaeus-Merzbacher disease]] [MIM #312080] is an X-linked recessive disorder.
   
 
{| cellpadding=3 cellspacing=0 border=1 style="border-collapse:collapse"
 
{| cellpadding=3 cellspacing=0 border=1 style="border-collapse:collapse"
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| [[Autosomal]] [[loci]] or [[phenotypes]] (created after May 15, 1994)
 
| [[Autosomal]] [[loci]] or [[phenotypes]] (created after May 15, 1994)
 
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|}
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These codes have been used in the medical literature to provide a unified index to genetic diseases.<ref>{{cite pmid|8592332}}</ref>
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==See also==
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* [[Comparative Toxicogenomics Database]], a database that integrates chemicals and genes with human diseases, including OMIM data.
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* [[DECIPHER]], a database of chromosomal imbalance and associated phenotype in humans, using [[Ensembl]] resources.
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* [[Medical classification]]
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* [[Mendelian inheritance]]
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* [[Online Mendelian Inheritance in Animals]]
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==References==
 
==References==
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* McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders. Baltimore, MD: The Johns Hopkins University Press, 1998. ISBN 0-8018-5742-2.
 
* McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders. Baltimore, MD: The Johns Hopkins University Press, 1998. ISBN 0-8018-5742-2.
   
==See also==
 
* [[Medical classification]]
 
   
 
== External link ==
 
== External link ==
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[[Category:Bioinformatics]] [[Category:Diagnosis classification]]
 
[[Category:Bioinformatics]] [[Category:Diagnosis classification]]
   
:es:Herencia Mendeliana en el Hombre
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:fr:Héritage mendélien chez l'Homme
 
:he:OMIM
 
:hu:Mendeli öröklődés emberben adatbázis
 
:pt:Online Mendelian Inheritance in Man
 
 
{{enWP|OMIM}}
 
{{enWP|OMIM}}

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Online Mendelian Inheritance in Man (OMIM) is a database that catalogues all the known diseases with a genetic component, and — when possible — links them to the relevant genes in the human genome and provides references for further research and tools for genomic analysis of a catalogued gene.[1] OMIM is one of the databases housed in the U.S. National Center for Biotechnology Information (NCBI) and included in its search menus.[2]

Versions Edit

Mendelian Inheritance in Man was started in the early 1960s[3] and is available as a book currently in its 12th edition.[4] The online version, OMIM, has been available since 1987,[5] moved to the World Wide Web by NCBI in 1995,[3] and in 2004 contained more than 15,000 records.[1]


Collection processEdit

The information in this database is collected and processed under the leadership of Dr. Victor A. McKusick at Johns Hopkins University, assisted by a team of science writers and editors. Relevant articles are identified, discussed and written up in the relevant entries in the MIM database

The MIM codeEdit

Every disease and gene is assigned a six digit number of which the first number classifies the method of inheritance.

If the initial digit is 1, the trait is deemed autosomal dominant; if 2, autosomal recessive; if 3, X-linked. Wherever a trait defined in this dictionary has a MIM number, the number from the 12th edition of MIM, is given in square brackets with or without an asterisk (asterisks indicate that the mode of inheritance is known; a number symbol (#) before an entry number means that the phenotype can be caused by mutation in any of two or more genes) as appropriate e.g., Pelizaeus-Merzbacher disease [MIM #312080] is an X-linked recessive disorder.

First Digit Range of MIM codes Method of inheritance
1 100000-199999 Autosomal loci or phenotypes (created before May 15, 1994)
2 200000-299999 Autosomal loci or phenotypes (created before May 15, 1994)
3 300000-399999 X-linked loci or phenotypes
4 400000-499999 Y-linked loci or phenotypes
5 500000-599999 Mitochondrial loci or phenotypes
6 600000- Autosomal loci or phenotypes (created after May 15, 1994)

These codes have been used in the medical literature to provide a unified index to genetic diseases.[6]

See alsoEdit


ReferencesEdit

  • Table from the OMIM FAQ
  • McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders. Baltimore, MD: The Johns Hopkins University Press, 1998. ISBN 0-8018-5742-2.


External link Edit

Databases supported by Bioinformatic Harvester
UniProt | SOURCE | SMART | SOSUI | PSORT | HomoloGene | GFP-cDNA | IPI | OMIM
NCBI-BLAST | Genome-Browser | Ensembl | RZPD | STRING | iHOP | Entrez


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Cite error: <ref> tags exist, but no <references/> tag was found

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