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Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Olivopontocerebellar atrophy (OPCA) is a term used to define neuronal degeneration in the cerebellum, pontine nuclei, and inferior olive. The use of the term has changed considerably in recent years thanks to the progressing knowledge of the genetic bases of the disease.
Four types of hereditary OPCA have disappeared from medical nomenclature, as they have been found to be the same as an already classified form of spinocerebellar atrophy. Type 2, autosomal recessive and Type 5 are still classified as olivopontocerebellar atrophy, though when their genetic associations are identified they may be renamed or combined with other conditions.
|OPCA number||OPCA name||SCA #||Gene||OMIM|
|OPCA type 1||"Menzel type OPCA"||SCA1||ATXN1||164400|
|OPCA type 2, autosomal dominant||"Holguin type OPCA"||SCA2||ATXN2||183090|
|OPCA type 2, autosomal recessive||"Fickler-Winkler type OPCA"||none known||?||258300|
|OPCA type 3||"OPCA with retinal degeneration"||SCA7||ATXN7||164500|
|OPCA type 4||"Schut-Haymaker type OPCA"||SCA1||ATXN1||164400|
|OPCA type 5||"OPCA with dementia and extrapyramidal signs"||none known||?||164700|
- GPnotebook -113967058 - "olivopontocerebellar atrophy"
- GPnotebook -429195218 - "lethal olivopontocerebellar atrophy"
- Who Named It synd/1903 - "Dejerine-Thomas atrophy"
- opca at NINDS
Nervous system pathology, primarily PNS (G50-G99, 350-359)
|Nerve, nerve root|
and plexus disorders
cranial nerve: V (Trigeminal neuralgia) - VII (Facial nerve paralysis, Bell's palsy, Melkersson-Rosenthal syndrome, Central seven) - XI (Accessory nerve disorder)
and other disorders of the PNS
| Diseases of myoneural junction|
Myasthenia gravis - Primary disorders of muscles (Muscular dystrophy, Myotonic dystrophy, Myotonia congenita, Thomsen disease, Neuromyotonia, Paramyotonia congenita, Centronuclear myopathy, Nemaline myopathy, Mitochondrial myopathy) - Myopathy - Periodic paralysis (Hypokalemic, Hyperkalemic) - Lambert-Eaton myasthenic syndrome
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