Nucleus raphe obscurus

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Brain: Nucleus raphe obscurus
Section of the medulla oblongata at about the middle of the olive. (Raphe nuclei not labeled, but 'raphe' labeled at left.)
[[Image:|250px|center|]]
Latin	nucleus raphes obscurus
Gray's	subject #
Part of
Components
Artery
Vein
BrainInfo/UW	hier-737
MeSH	[1]

The nucleus raphe obscurus, despite the implications of its name, has some very specific functions and connections of afferent and efferent nature. The raphe obscurus projects to the cerebellar lobes VI and VII and to crus II along with the nucleus raphe pontis ^[1].

This so called obscure nucleus has also been implicated in the modulation of the hypoglossal nerve. It has been observed that the ablation of this nucleus causes a change in the firing pattern in the XII nerve ^[2].

In addition, the raphe obscurus mediates expiration via the inhibitory effect of serotonin and depresses periodic synaptic potentials ^[3]. It has also been shown that this nucleus stimulates gastrointestinal motor function; microinjections of 5-HT into the n.r. obscurus increase gastric movement ^[4].

[edit] See also

• Raphe nuclei

[edit] References

1. ↑ Brodal, A. Neurological Anatomy in relation to Clinical Medication 3rd ed. Oxford Press. 1981
2. ↑ Peever JH, Necakov A, Duffin J., "Nucleus raphe obscurus modulates hypoglossal output of neonatal rat in vitro transverse brain stem slices." Journal of Appl Physiol. 2001 Jan;90(1):269-79
3. ↑ Lalley PM, Benacka R, Bischoff AM, Richter DW, "Nucleus raphe obscurus evokes 5-HT-1A receptor-mediated modulation of respiratory neurons". Brain Research Volume 747, Issue 1 , 30 January 1997, Pages 156-159
4. ↑ Krowicki, ZK and Hornby, PJ. "Serotonin microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally mediated pathway", Pharmacology and Experimental Therapeutics. Volume 265, Issue 1, pp. 468-476, 04/01/1993

v·d·e Brain: rhombencephalon (hindbrain)
Metencephalon/ pons	{| class="navbox collapsible nowraplinks" style="margin:auto; background:white;background:white;"
[[[:Template:Fullurl:Template:]] v]·[[[:Template:Fullurl:Template talk:]] d]·[[[:Template:Fullurl:Template:]] e]
Dorsal/ (tegmentum)	surface: Locus ceruleus Trigeminal lemniscus (Dorsal trigeminal tract, Ventral trigeminal tract) cranial nuclei: GSA: Principal V/Spinal V - VIII-c (Dorsal, Anterior)/VIII-v (Lateral, Superior, Medial, Inferior) - SVE: Motor V - VII - GSE: VI - GVE: VII: Superior salivary nucleus MLF, III, IV and VI (vestibulo-oculomotor fibers, medial vestibulospinal tract) sensory/ascending: Trapezoid body/VIII - Superior olivary nucleus Inferior cerebellar peduncle (Vestibulocerebellar tract) motor/descending: Apneustic center • Pneumotaxic center (Medial parabrachial nucleus) - Lateral parabrachial nucleus
Ventral/ (base)	Middle cerebellar peduncles (Pontocerebellar fibers) - Pontine nuclei motor/descending: Corticospinal tract - Corticobulbar tract - Corticopontine fibers
Raphe/reticular	Reticular formation (Caudal, Oral, Tegmental, Paramedian) • Raphe nuclei (Median)

|- style="white-space:nowrap;background:#ddddff;text-align:right;background-color: LightYellow" ! Myelencephalon/
medulla | colspan="1" style="text-align:left;width:100%;font-size:95%;background:#f7f7f7;" | {| class="navbox collapsible nowraplinks" style="margin:auto; background:white;background:white;" |- style="text-align:center;width:100%;"

!colspan="2" |

|- |- style="white-space:nowrap;background:#ddddff;text-align:right;padding-left:0em;padding-right:0em;background-color: LightYellow"

!

| colspan="1" style="text-align:left;width:100%;font-size:95%;" | surface: Posterior median sulcus - Postero-lateral sulcus - Area postrema

cranial nuclei: GVA: VII,IX,X: Solitary/tract • SVA: Gustatory nucleus • GSE: XII  • GVE: IX,X,XI: Ambiguus • SVE: X: Dorsal • IX: Inferior salivatory nucleus - MLF, III, IV and VI

sensory/ascending: Gracile nucleus • Cuneate nucleus (Accessory cuneate nucleus) • Sensory decussation  • Medial lemniscus

motor/descending: Dorsal respiratory group
|- style="white-space:nowrap;background:#ddddff;text-align:right;padding-left:0em;padding-right:0em;background-color: LightYellow"

!

| colspan="1" style="text-align:left;width:100%;font-size:95%;background:#f7f7f7;" | motor/descending: Ventral respiratory group - Pyramid (Motor decussation) - Inferior olivary nucleus (Olivocerebellar tract, Rubro-olivary tract)
surface: Anterior median fissure - Antero-lateral sulcus - Arcuate nucleus of medulla - Olivary body
|- style="white-space:nowrap;background:#ddddff;text-align:right;padding-left:0em;padding-right:0em;background-color: LightYellow"

!

| colspan="1" style="text-align:left;width:100%;font-size:95%;" | Reticular formation (Gigantocellular, Parvocellular, Ventral, Lateral, Paramedian) • Raphe nuclei (Obscurus, Magnus, Pallidus) |} |}

This page uses content from the English-language version of Wikipedia. The original article was at Nucleus raphe obscurus. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.