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Nissl body

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Image of a Nissl-stained histological section through the rodent hippocampus showing various classes of neurons.


Motor nerve cell from ventral horn of medulla spinalis of rabbit. The angular and spindle-shaped Nissl bodies are well shown.

A Nissl body (or Nissl granule or tigroid body) is a large granular body found in nerve cells. It was named after Franz Nissl, German neurologist (1860-1919).

Nissl bodies can be demonstrated by selective staining, which was developed by Nissl and was an aniline stain used to label extranuclear RNA granules.

These granules are rough endoplasmic reticulum (with ribosomes) and are the site of protein synthesis.

Nissl bodies show changes under various physiological conditions and in pathological conditions they may dissolve and disappear (karyolysis).

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External linksEdit

fr:coloration de Nissl

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