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A Nissl body (or Nissl granule or tigroid body) is a large granular body found in nerve cells. It was named after Franz Nissl, German neurologist (1860-1919).
Nissl bodies can be demonstrated by selective staining, which was developed by Nissl and was an aniline stain used to label extranuclear RNA granules.
These granules are rough endoplasmic reticulum (with ribosomes) and are the site of protein synthesis.
Nissl bodies show changes under various physiological conditions and in pathological conditions they may dissolve and disappear (karyolysis).
- fr:coloration de Nissl
|Histology: nervous tissue|
|Neurons (gray matter)
soma, axon (axon hillock, axoplasm, axolemma, neurofibril/neurofilament), dendrite (Nissl body, dendritic spine, apical dendrite, basal dendrite)
types (bipolar, pseudounipolar, multipolar, pyramidal, Purkinje, granule)
| Afferent nerve/Sensory nerve/Sensory neuron
GSA, GVA, SSA, SVA, fibers (Ia, Ib or Golgi, II or Aβ, III or Aδ or fast pain, IV or C or slow pain)
| Efferent nerve/Motor nerve/Motor neuron
GSE, GVE, SVE, Upper motor neuron, Lower motor neuron (α motorneuron, γ motorneuron)
neuropil, synaptic vesicle, neuromuscular junction, electrical synapse - Interneuron (Renshaw)
| Sensory receptors
Free nerve ending, Meissner's corpuscle, Merkel nerve ending, Muscle spindle, Pacinian corpuscle, Ruffini ending, Olfactory receptor neuron, Photoreceptor cell, Hair cell, Taste bud
| Glial cells
astrocyte, oligodendrocyte, ependymal cells, microglia, radial glia
| Myelination (white matter)
Schwann cell, oligodendrocyte, nodes of Ranvier, internode, Schmidt-Lanterman incisures, neurolemma
| Related connective tissues
epineurium, perineurium, endoneurium, nerve fascicle, meninges