Nicotinic antagonist

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A nicotinic antagonist is a type of anticholinergic which inhibits the action at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, but some centrally acting compounds such as mecamylamine and 18-methoxycoronaridine block nicotinic acetylcholine receptors in the brain and can be used for treating drug addiction.

Comparison

Mechanism	Antagonist	Preferred receptor	Clinical use
Ganglionic blocking agents	Hexamethonium	Ganglion type	none[1]
	Mecamylamine	Ganglion type
	Trimethaphan	Ganglion type	Rarely used for blood pressure decrease during surgery[1]
Nondepolarizing neuromuscular blocking agents	Atracurium	Muscle type	muscle relaxant in anaesthesia[1]
	Doxacurium	Muscle type
	Mivacurium	Muscle type
	Pancuronium	Muscle type	muscle relaxant in anaesthesia[1]
	Tubocurarine	Muscle type	Rarely used [1]
	Vecuronium	Muscle type	muscle relaxant in anaesthesia[1]
Depolarizing neuromuscular blocking agents	Succinylcholine	Muscle type
Centrally acting nicotinic antagonists	18-Methoxycoronaridine	α3β4

[edit] References

[edit] External links

• MeSH Nicotinic+antagonists

Template:Pharmacology-stub Template:Antihypertensives and diuretics

v·d·e Muscle relaxants (M03)
Peripherally acting (primarily antinicotinic, neuromuscular-blocking drugs)	curare alkaloids (Alcuronium, Dimethyltubocurarine, Tubocurarine) - choline derivatives (Suxamethonium) - other quaternary ammonium compounds (Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Vecuronium) - other (Botulinum toxin)
Centrally acting	carbamic acid esters (Phenprobamate, Carisoprodol, Methocarbamol, Styramate, Febarbamate), Baclofen, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Lorazepam, Mephenesin, Orphenadrine, Phenyramidol, Pridinol, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone
Directly acting	Dantrolene

v·d·e Receptor agonists, antagonists, and reuptake inhibitors
Dopamine receptor	Dopamine agonist • Dopamine antagonist • Dopamine reuptake inhibitor
5-HT (serotonin) receptor	Serotonin receptor agonist • Serotonin antagonist (5-HT3) • Serotonin uptake inhibitor (SSRI)
Adrenergic receptor	Adrenergic agonist (Alpha, Beta2) • Adrenergic antagonist (Alpha, Beta) • Adrenergic uptake inhibitor
Acetylcholine receptor	Cholinergic (Muscarinic, Nicotinic) • Anticholinergic (Muscarinic, Nicotinic) • Acetylcholinesterase inhibitor
Histamine receptor	Histamine agonist • Histamine antagonist (H1, H2)
GABA receptor	GABA agonist • GABA antagonist
NMDA receptor	NMDA receptor antagonist

This page uses content from the English-language version of Wikipedia. The original article was at Nicotinic antagonist. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.