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Neurosyphilis refers to a site of infection involving the central nervous system (CNS). Neurosyphilis may occur at any stage of syphilis. Before the advent of antibiotics, it was typically seen in 25-35% of patients with syphilis. Neurosyphilis is now most common in patients with HIV infection. Reports of neurosyphilis in HIV-infected persons are similar to cases reported before the HIV pandemic. The precise extent and significance of neurologic involvement in HIV-infected patients with syphilis, reflected by either laboratory or clinical criteria, have not been well characterized. Furthermore, the alteration of host immunosuppression by antiretroviral therapy in recent years has further complicated such characterization.

There are four clinical types of neurosyphilis:

The late forms of neurosyphilis (tabes dorsalis and general paresis) are seen much less frequently since the advent of antibiotics. The most common manifestations today are asymptomatic or symptomatic meningitis. Acute syphilitic meningitis usually occurs within the first year of infection; 10% of cases are diagnosed at the time of the secondary rash. Patients present with headache, meningeal irritation, and cranial nerve abnormalities, especially the optic nerve, facial nerve, and the vestibulocochlear nerve. Rarely, it affects the spine instead of the brain, causing focal muscle weakness or sensory loss.

Meningovascular syphilis occurs a few months to 10 years (average, 7 years) after the primary syphilis infection. Meningovascular syphilis can be associated with prodromal symptoms lasting weeks to months before focal deficits are identifiable. Prodromal symptoms include unilateral numbness, paresthesias, upper or lower extremity weakness, headache, vertigo, insomnia, and psychiatric abnormalities such as personality changes. The focal deficits initially are intermittent or progress slowly over a few days. However, it can also present as an infectious arteritis and cause an ischemic stroke, an outcome more commonly seen in younger patients. Angiography may be able to demonstrate areas of narrowing in the blood vessels or total occlusion.

General paresis, otherwise known as general paresis of the insane, is a severe manifestation of neurosyphilis. It is a chronic dementia which ultimately results in death in as little as 2-3 years. Patients generally have progressive personality changes, memory loss, and poor judgment. More rarely, they can have psychosis, depression, or mania. Imaging of the brain usually shows atrophy.


Symptoms and signs[]

Symptoms of neurosyphilis include:[2]

  • Abnormal gait
  • Blindness
  • Confusion
  • Dementia
  • Depression
  • Headache
  • Incontinence
  • Irritability
  • Numbness in the toes, feet, or legs
  • Poor concentration
  • Seizures
  • Neck stiffness
  • Tremors
  • Visual disturbances. There may be the sign of Argyll Robertson pupils, which are bilateral small pupils that constrict when the patient focuses on a near object, but do not constrict when exposed to bright light.
  • Muscle weakness

Upon further diagnostic workup, the following signs may be present:

  • Abnormal reflexes
  • Muscle atrophy
  • Muscle contractions


Approximately 35% to 40% of persons with secondary syphilis have asymptomatic central nervous system (CNS) involvement, as demonstrated by any of these on cerebrospinal fluid (CSF) examination:

  • An abnormal leukocyte cell count, protein level, or glucose level
  • Demonstrated reactivity to Venereal Disease Research Laboratory (VDRL) antibody test

Diagnosis[]

In addition to evaluation of any symptoms and signs, various blood tests can be done:[2]

  • Venereal Disease Research Laboratory test (VDRL)
  • Fluorescent treponemal antibody absorption (FTA-ABS)
  • Rapid plasma reagin (RPR)
  • Treponema pallidum particle agglutination assay (TPPA)

Also, it is important to test the cerebrospinal fluid for signs of syphilis.[2]

Additional tests to look for problems with the nervous system may include:[2]

Treatment[]

Penicillin is used to treat neurosyphilis. Two examples of penicillin therapies include:[2]

  • Injection into a vein several times a day for 10 - 14 days.
  • One daily intramuscular injection and oral probenecid 4 times a day, both for 10 - 14 days.

Follow-up blood tests are generally performed at 3, 6, 12, 24, and 36 months to make sure the infection is gone.[2] Lumbar punctures for CSF fluid analysis are generally performed every 6 months.



See also[]

References[]

  1. Richard B. Jamess, MD, PhD (2002). Syphilis- Sexually Transmitted Infections, 2006.. Sexually transmitted diseases treatment guidelines.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Cite error: Invalid <ref> tag; no text was provided for refs named pubmedhealth

Further reading[]

  • Alliez, J., & Sormani, J. (1968). Hallucinatory psychosis and syphilis: Annales Medico-Psychologiques 2(3) 1968, 404.
  • Almeida, O. P., & Lautenschlager, N. T. (2005). Dementia associated with infectious diseases: International Psychogeriatrics Vol 17(Suuppl1) 2005, S65-S77.
  • Aronow, H. A., Brew, B. J., & Price, R. W. (1988). The management of the neurological complications of HIV infection and AIDS: AIDS Vol 2(Suppl 1) 1988, 151-159.
  • Bach, F., & Worster-Drought, C. (1930). Interrelation of neurosyphilis and cardiovascular syphilis: Lancet 2 1930, 1113-1115.
  • Ban, T. A. (2001). Pharmacotherapy of mental illness--A historical analysis: Progress in Neuro-Psychopharmacology & Biological Psychiatry Vol 25(4) May 2001, 709-727.
  • Bennett, A. E. (1923). Neurosyphilis in the Aged. A Study of Nineteen Cases of Senile Neurosyphilis Occurring in a Series of 2,175 Cases of All Types of Nervous Syphilis: Archives of Neurology & Psychiatry (Chicago) 10 1923, 324-328.
  • Berger, J. R. (1991). Neurosyphilis in human immunodeficiency virus Type 1-seropositive individuals: A prospective study: Archives of Neurology Vol 48(7) Jul 1991, 700-702.
  • Berkowitz, H. L. (2002). Argyll-Robertson pupil and neurosyphilis: Psychosomatics: Journal of Consultation Liaison Psychiatry Vol 43(4) Jul-Aug 2002, 340-341.
  • Bertucelli, L., Bensmail, B., & Bencharif, A. K. (1968). Neurosyphilis: Annales Medico-Psychologiques 1(5) 1968, 768.
  • Blatz, R., Kuhn, H. J., Hermann, W., Rytter, M., & Rodloff, A. C. (2005). Neurosyphilis and neuroborreliosis: Retrospective evaluation of 22 cases: Nervenarzt Vol 76(6) Jun 2005, 724-732.
  • Boyle, A., Zafar, R., Riley, V., & Lindesay, J. (1995). Neurosyphilis presenting with dissociative symptoms: Journal of Neurology, Neurosurgery & Psychiatry Vol 59(4) Oct 1995, 452-453.
  • Brinar, V. V., & Habek, M. (2007). Dementia and white-matter demyelination in young patient with neurosyphilis: Lancet Vol 368(9554) Dec-Jan 2007, 2258.
  • Brooke, D., Jamie, P., Slack, R., Sulaiman, M., & et al. (1987). Neurosyphilis: A treatable psychosis: British Journal of Psychiatry Vol 151 Oct 1987, 556.
  • Burke, J. M., & Schaberg, D. R. (1985). Neurosyphilis in the antibiotic era: Neurology Vol 35(9) Sep 1985, 1368-1371.
  • Caiazza, S. S. (1988). Neuropsychiatric AIDS and neurosyphilis: Overlap: Journal of Orthomolecular Medicine Vol 3(3) 1988, 117-122.
  • Calderon, W., Douville, H., Nigro, M., Bono, G., & et al. (1990). Concomitant syphilitic and HIV infection: A case report: Acta Neurologica Vol 12(2) Apr 1990, 132-137.
  • Cirera, E., Fluvia, X., Perez, P., & Salto, C. (1988). Organic mental disorder induced by neurosyphilis: A clinical case: Revista del Departamento de Psiquiatria de la Facultad de Medicina de Barcelona Vol 15(3) May-Jun 1988, 152-158.
  • Conrad, B., & et al. (1983). Visual evoked potentials in neurosyphilis: Journal of Neurology, Neurosurgery & Psychiatry Vol 46(1) Jan 1983, 23-27.
  • Dattner, B. (1948). Failures in treatment of neurosyphilis. Oxford, England: Grune & Stratton.
  • Dawson, G., & Baldwin, B. (1996). Neurosyphilis and secondary mania in elderly patients: Irish Journal of Psychological Medicine Vol 13(1) Mar 1996, 24-25.
  • Dennie, C. C. (1930). Familial neurosyphilis: Journal of the American Medical Association 95 1930, 1571-1576.
  • Desparois, G. B. (1927). Report of a case of neurosyphilis: Med J & Rec 125 1927, 667.
  • Dewhurst, K. (1968). Atypical serology in neurosyphilis: Journal of Neurology, Neurosurgery & Psychiatry 31(5) 1968, 496-500.
  • Dewhurst, K. (1968). Rapidly progressive cases of neurosyphilitic psychosis: Psychiatria Clinica 1(5) 1968, 320-326.
  • Domingos, K. A. (1995). The neuropsychological effects of syphilis. Dissertation Abstracts International: Section B: The Sciences and Engineering.
  • Duffy, J. D. (1995). General paralysis of the insane: Neuropsychiatry's first challenge: Journal of Neuropsychiatry & Clinical Neurosciences Vol 7(2) Spr 1995, 243-249.
  • Dunivin, D. L., & Foust, M. J., Jr. (1999). A case study from the Department of Defense Psychopharmacology Demonstration Project: Mania and neurosyphilis: Professional Psychology: Research and Practice Vol 30(4) Aug 1999, 346-351.
  • Epstein, S. H. (1943). The neurological effects of syphilis: Journal of Nervous and Mental Disease 97 1943, 11-26.
  • Estevez, R. F. (2006). Neurosyphilis Presenting as Rhabdomyolysis and Acute Renal Failure with Subsequent Irreversible Psychosis and Dementia: Psychosomatics: Journal of Consultation Liaison Psychiatry Vol 47(6) Nov-Dec 2006, 538-539.
  • Finley, K. H., Rose, A. S., & Solomon, H. C. (1941). Electroencephalographic studies in neurosyphilis: Transactions of the American Neurological Association 67 1941, 136-139.
  • Fonseca Costa, G. (1983). Profession and origin of neurosyphilis disease patients at a psychiatric hospital over a period of 50 years (1930-1979): Acta Psiquiatrica y Psicologica de America Latina Vol 29(2) Jun 1983, 111-115.
  • Fox, P. A., Hawkins, D. A., & Dawson, S. (2000). Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1-positive patient: AIDS Vol 14(13) Sep 2000, 2062-2063.
  • Galindo Menendez, A. (1996). Parenchymal neurosyphilis: Insidious onset (dementia) and acute onset (manic type) forms: Actas Luso-Espanolas de Neurologia, Psiquiatria y Ciencias Afines Vol 24(5) Sep-Oct 1996, 261-267.
  • Gastal, F. L., Leite, S. S. O., Andreoli, S. B., Gameiro, M. A., Gastal, C. L., Gazalle, F. K., et al. (1999). Etiological treatment in psychiatry: The neurosyphilis model: Revista Brasileira de Psiquiatria Vol 21(1) Jan-Mar 1999, 29-35.
  • Gilpin, S. F., Jr. (1948). Neurosyphilis: Spiegel, E A.
  • Gliatto, M. F., & Caroff, S. N. (2001). Neurosyphilis: A history and clinical review: Psychiatric Annals Vol 31(3) Mar 2001, 153-161.

Greenblatt, M., & Levin, S. (1945). Factors affecting the electroencephalogram of patients with neurosyphilis: American Journal of Psychiatry 102 1945, 40-48.

  • Haeger, B. (1987). Water intoxication in congenital neurosyphilis: British Journal of Psychiatry Vol 150 May 1987, 722-723.
  • Hecht, S. (1927). Treatment of neurosyphilis: Med J & Rec 125 1927, 403-405.
  • Hoffman, B. F. (1982). Reversible neurosyphilis presenting as chronic mania: Journal of Clinical Psychiatry Vol 43(8) Aug 1982, 338-339.
  • Hooshmand, H. (1976). Seizure disorders associated with neurosyphilis: Diseases of the Nervous System Vol 37(3) Mar 1976, 133-136.
  • Hutto, B. (2001). Syphilis in clinical psychiatry: A review: Psychosomatics: Journal of Consultation Liaison Psychiatry Vol 42(6) Nov-Dec 2001, 453-460.
  • Hyder, H. P. (1924). The relation of salvarsan to neurosyphilis: Journal of Nervous and Mental Disease 60 1924, 479-484.
  • Ide, M., Mizukami, K., Fujita, T., Ashizawa, Y., & Asada, T. (2004). A case of neurosyphilis showing a marked improvement of clinical symptoms and cerebral blood flow on single photon emission computed tomography with quantitative penicillin treatment: Progress in Neuro-Psychopharmacology & Biological Psychiatry Vol 28(2) Mar 2004, 417-420.
  • Kemp, J. E., & Poole, A. K. (1925). Familial neurosyphilis IV. Incidence of neurosyphilis among the parents of congenitally neurosyphilitic children: J Amer Med Ass 84 1925, 1395-1398.
  • Kohler, C. G., Pickholtz, J., & Ballas, C. (2000). Neurosyphilis presenting as schizophrenialike psychosis: Neuropsychiatry, Neuropsychology, & Behavioral Neurology Vol 13(4) Oct 2000, 297-302.
  • la Mancusa, J. C., & Cole, A. R. (1987). Suspected neurosyphilis in a hospitalized eighty-year-old patient with dementia: Issues in diagnosis and treatment: Clinical Gerontologist Vol 7(1) Fal 1987, 33-39.
  • Lair, L., & Naidech, A. M. (2004). Modern neuropsychiatric presentation of neurosyphilis: Neurology Vol 63(7) Oct 2004, 1331-1333.
  • Laks, J., & Santos, M. A. (1989). The diagnosis of psycho-organic syndromes: A case report of neurosyphilis: Jornal Brasileiro de Psiquiatria Vol 38(5) Sep-Oct 1989, 279-283.
  • Lauria, G., Erbetta, A., Pareyson, D., & Sghirlanzoni, A. (2001). Parenchymatous neurosyphilis: Neurological Sciences Vol 22(3) 2001, 281-282.
  • Lee, J. W., Wilck, M., & Venna, N. (2005). Dementia due to neurosyphilis with persistently negative CSF VDRL: Neurology Vol 65(11) Dec 2005, 1838.
  • Leite Gastal, F., Olive Leite, S. S., Carnieletto, G. E., Carnieletto Junior, A., & et al. (1995). Atypical neurosyphilis: Case report: Arquivos de Neuro-Psiquiatria Vol 53(3) Sep 1995, 494-497.
  • Lennox, W. G. (1923). Neurosyphilis Among the Chinese: Archives of Neurology & Psychiatry (Chicago) 9 1923, 26-33.
  • Lewis, N. D. C., Hubbard, L. D., & Dyar, E. G. (1924). The Malarial Treatment of Paretic Neurosyphilis: American Journal of Psychiatry 4 1924, 175-226.
  • Lowenstein, O. (1935). Disturbances of the pupillary light reflex in luetic diseases of the central nervous system. Contributions to the early diagnostics of neurosyphilis. Oxford, England: Schwabe.
  • Lukacher, G. Y., & Chudnovsky, V. A. (1987). The diagnosis and forensic psychiatric expert medical examination in neurosyphilis: Zhurnal Nevropatologii i Psikhiatrii imeni S S Korsakova Vol 87(11) 1987, 1704-1710.
  • Luque, O. (1946). Concerning a case of ophthalmoplegia in neuro-syphilis; dissociation between voluntary and reflex motility: Revista Argentina de Neurologia y Psiquiatria, Rosario 11 1946, 24-30.
  • Mahendran, R. (2001). Clozapine in the treatment of hypomania with neurosyphilis: Journal of Clinical Psychiatry Vol 62(6) Jun 2001, 477-478.
  • Masten, M. G. (1929). Inherited neurosyphilis: Journal of Nervous and Mental Disease 70 1929, 379-389.
  • McArthur, J. C., Ashe, J., & Jabs, D. (1990). Diagnosis and treatment of neurologic disorders in AIDS and other sexually transmitted diseases. New York, NY, England: Plenum Medical Book Co/Plenum Press.
  • Mella, H., & Katz, S. E. (1924). Neurosyphilis as an etiological factor in the Parkinsonian syndrome: Journal of Nervous and Mental Disease 59 1924, 225-230.
  • Menninger, W. C. (1935). Juvenile paretic neurosyphilis studies. III. Developmental history including mental and physical growth, trauma, and convulsions: Journal of Nervous and Mental Disease 81 1935, 489-503.
  • Menninger, W. C. (1936). The psychology of juvenile paretic neurosyphilis: Psychoanalytic Review 23 1936, 76-83.
  • Merritt, H. H., & Moore, M. (1933). The Argyll-Robertson pupil: an anatomic-physiologic explanation of the phenomenon, with a survey of its occurrence in neurosyphilis: Archives of Neurology and Psychiatry 30 1933, 357-373.
  • Mirsal, H., Kalyoncu, A., Pektas, O., & Beyazyurek, M. (2007). Neurosyphilis presenting as psychiatric symptoms: An unusual case report: Acta Neuropsychiatrica Vol 19(4) Aug 2007, 251-253.
  • Moore, J. R., & Sutton, I. C. (1926). Tryparsamide in the treatment of late neurosyphilis: Journal of Nervous and Mental Disease 63 1926, 569-574.
  • Negulici-Baliff, E., & Cristodoresco, D. (1967). Epilepsy and neurosyphilis: Acta Neurologica et Psychiatrica Belgica 67(12) 1967, 1138-1152.
  • Neymann, C. A., & Singleton, D. E. (1926). Therapeutic results with tryparsamide in the treatment of neurosyphilis: Journal of Nervous and Mental Disease 64 1926, 144-150.
  • Nicol, W. D. (1948). Neurosyphilis; a review of recent literature: Postgraduate Medical Journal 24 1948, 25-30.
  • Nicol, W. D. (1950). Neuro-syphilis and its treatment. Oxford, England: Churchhill.
  • Odobesco, G. I., & Vasilesco, H. (1933). Schizophrenia and neurosyphilis: Annales Medico-Psychologiques 91 1933, 652-665.
  • O'Leary, P. A. (1931). Treatment by malaria in asymptomatic neurosyphilis: Journal of the American Medical Association 97 1931, 1585.
  • Palicio, L., & Basauri, V. A. (1996). Neurosyphilis with psychiatric manifestations: A forgotten condition? : Irish Journal of Psychological Medicine Vol 13(1) Mar 1996, 26-27.
  • Patkar, A. A., Peng, A. T., & Alexander, R. C. (1997). Neurosyphilis occurring in a patient with schizophrenia: A cautionary tale: Journal of Nervous and Mental Disease Vol 185(2) Feb 1997, 119-120.
  • Pavlovsky, P. (1977). A few comments on present-day problems of neurosyphilis: Cesko-Slovenska Psychiatrie Vol 73(3) 1977, 199-202.
  • Raeder, O. J. (1920). Interim report on the neurosyphilis investigation of the Massachusetts commission on mental diseases: American Journal of Insanity 76 1920, 449-464.
  • Reisecker, F., Koltringer, P., Lind, P., Leblhuber, F., & et al. (1992). Lack of specificity of SPECT with dementia: A case of paralytic neurosyphilis: Nervenarzt Vol 63(6) Jun 1992, 371-374.
  • Rosanoff, A. J. (1938). Neurosyphilis. Hoboken, NJ: John Wiley & Sons Inc.
  • Ross, R. L., Smith, G. R., & Guggenheim, F. G. (1990). Neurosyphilis and organic mood syndrome: A forgotten diagnosis: Psychosomatics: Journal of Consultation Liaison Psychiatry Vol 31(4) Fal 1990, 448-450.
  • Rozwens, A., Radziwillowicz, P., Jakuszkowiak, K., & Cubala, W. J. (2003). Neurosyphilis with its psychopathological implications. Literature review: Psychiatria Polska Vol 37(3) May-Jun 2003, 477-494.
  • Rundell, J. R., & Wise, M. G. (1985). Neurosyphilis: A psychiatric perspective: Psychosomatics: Journal of Consultation Liaison Psychiatry Vol 26(4) Apr 1985, 287-295.
  • Russouw, H. G., Roberts, M. C., Emsley, R. A., & Truter, R. (1997). Psychiatric manifestations and magnetic resonance imaging in HIV-negative neurosyphilis: Biological Psychiatry Vol 41(4) Feb 1997, 467-473.
  • Sachs, B. (1985). On the present role of neurolues in the differential diagnosis of neuropsychiatric clinical pictures: Psychiatrie, Neurologie und Medizinische Psychologie Vol 37(7) Jul 1985, 416-420.
  • Saik, S., Kraus, J. E., McDonald, A., Mann, S. G., & Sheitman, B. B. (2004). Neurosyphilis in Newly Admitted Psychiatric Patients: Three Case Reports: Journal of Clinical Psychiatry Vol 65(7) Jul 2004, 919-921.
  • Sanchez, F. M., & Zisselman, M. H. (2007). Treatment of psychiatric symptoms associated with neurosyphilis: Psychosomatics: Journal of Consultation Liaison Psychiatry Vol 48(5) Sep-Oct 2007, 440-445.
  • Sands, I. J. (1930). Subarachnoid hemorrhage as a clinical complication of neurosyphilis: Archives of Neurology and Psychiatry 24 1930, 85-93.
  • Sarbo, A. V. (1936). Concerning psychotic conditions in neurosyphilis: Archiv fur Psychiatrie und Nervenkrankheiten 105 1936, 304.
  • Simon, R. P. (1985). Neurosyphilis: Archives of Neurology Vol 42(6) Jun 1985, 606-613.
  • Sirota, P., Eviatar, J., & Spivak, B. (1989). Neurosyphilis presenting as psychiatric disorders: British Journal of Psychiatry Vol 155 Oct 1989, 559-561.
  • Sivakumar, K., & Okocha, C. I. (1992). Neurosyphilis and schizophrenia: British Journal of Psychiatry Vol 161 Aug 1992, 251-254.
  • Sobhan, T., Rowe, H. M., Ryan, W. G., & Munoz, C. (2004). Three Cases of Psychiatric Manifestations of Neurosyphilis: Psychiatric Services Vol 55(7) Jul 2004, 830-832.
  • Solomon, H. C., & Koefod, H. O. (1915). Notes on a conference on the medical and social aspects of syphilis of the nervous system. VII. The significance of changes in cellular content of cerebrospinal fluid in neurosyphilis: Boston Medical and Surgical Journal 173 1915, 996-1001.
  • Southard, E. E., & Solomon, H. C. (1916). Notes of a conference on the medical and social aspects of syphilis of the nervous system. VIII. Latent neurosyphilis and the question of general paresis--sine paresi: Boston Medical and Surgical Journal 174 1916, 8-15.
  • Southard, E. E., & Solomon, H. C. (1917). Neurosyphilis; modern systematic diagnosis and treatment: Pp 496 pp W M Leonard: Boston.
  • Stokes, J. H., & Shaffer, L. W. (1924). Results secured by standard methods of treatment in neurosyphilis: review of four hundred and five cases: Discussion 83 1924, 1831-1834.
  • Taycan, O., Ugur, M., & Ozmen, M. (2006). Quetiapine vs. risperidone in treating psychosis in neurosyphilis: A case report: General Hospital Psychiatry Vol 28(4) Jul-Aug 2006, 359-361.
  • Tiryaki, A., Kandemir, G., Aktepe, E., & Ak, I. (2005). Two Cases with Neurosyphilis Presenting in Various Clinical Manifestations: Klinik Psikiyatri Dergisi Vol 8(2) 2005, 100-104.
  • Toniolo, E. (1985). Delirium attacks in nonparalytic neurosyphilis: Psichiatria Generale e dell'Eta Evolutiva Vol 4 1985, 99-112.
  • Turan, S., Emul, M., Duran, A., Mert, A., & Ugur, M. (2007). Effectiveness of olanzapine in neurosyphilis related organic psychosis: A case report: Journal of Psychopharmacology Vol 21(5) Sep 2007, 556-558.
  • Vargas, A. P., Carod-Artal, F. J., del Negro, M. C., & Rodrigues, M. P. C. (2000). Dementia by neurosyphilis: Clinical and neuropsychological follow-up of a patient: Arquivos de Neuro-Psiquiatria Vol 58(2,B) Jun 2000, 578-582.
  • Vojvodic, N. M., Sokic, D. V., Jankovic, S. M., & Delic, S. (2003). Isolated episodes of status epilepticus as the manifestation of neurosyphilis: A case report: Comment: Epilepsia Vol 44(4) Apr 2003, 623.
  • Weaver, G., & Remick, R. A. (1982). Electroconvulsive treatment of depression associated with neurosyphilis: Journal of Clinical Psychiatry Vol 43(11) Nov 1982, 468-469.
  • Wetherill, M. B., Webb, H. E., & Catterall, R. D. (1965). Syphilis presented as an acute neurological illness: BMJ: British Medical Journal 1 1965, 1157.
  • Whelen, M., & Bree, M. H. (1946). Conducing to the cure; social psychiatry in the treatment of neurosyphilis by induced malaria: Lancet 251 1946, 477-480.
  • Wile, U. J., & Davenport, K. M. (1931). The malarial therapy of neurosyphilis other than uncomplicated dementia paralytica: Journal of the American Medical Association 97 1931, 1579.
  • Wilson, S. A. K. (1934). Discussion of unsettled questions of neurosyphilis: Proceedings of the Royal Society of Medicine 28 1934, 159-164.
  • Yorshis, M. (1928). A case of syringomyelia and neurosyphilis: New England Journal of Medicine 198 1928, 236-239.


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