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Neuropathic arthropathy

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"Charcot joint disease" redirects here. For the nerve disease, see Charcot-Marie-Tooth disease.
For several other diseases associated with Jean-Martin Charcot, see Jean-Martin Charcot.
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Neuropathic heel ulcer.jpg|
Neuropathic joint disease
ICD-10 M146
ICD-9 713.5
OMIM [1]
DiseasesDB 2344
MedlinePlus [2]
eMedicine orthoped/381 radio/476
MeSH {{{MeshNumber}}}

Neuropathic arthropathy (or neuropathic osteoarthropathy), also known as Charcot joint (often "Charcot foot"), refers to progressive degeneration of a weight bearing joint, a process marked by bony destruction, bone resorption, and eventual deformity. Onset is usually insidious.

If this pathological process continues unchecked, it could result in joint deformity, ulceration and/or superinfection, loss of function, and in the worst case scenario: amputation or death. Early identification of joint changes is the best way to limit morbidity.

PathogenesisEdit

Any condition resulting in decreased peripheral sensation, proprioception, and fine motor control:

Underlying MechanismsEdit

  • Two primary theories have been advanced:
    • Neurotrauma: Loss of peripheral sensation and proprioception leads to repetitive microtrauma to the joint in question; this damage goes unnoticed by the neuropathic patient, and the resultant inflammatory resorption of traumatized bone renders that region weak and susceptible to further trauma. Indeed, it is a vicious cycle. In addition, poor fine motor control generates unnatural pressure on certain joints, leading to additional microtrauma.
    • Neurovascular: Neuropathic patients have dysregulated autonomic nervous system reflexes, and de-sensitized joints receive significantly greater blood flow. The resulting hyperemia leads to increased osteoclastic resorption of bone, and this, in concert with mechanical stress, leads to bony destruction.

In reality, both of these mechanisms probably play a role in the development of a Charcot joint.

Joint InvolvementEdit

Diabetes is the foremost cause in America today for neuropathic joint disease,[citation needed] and the foot is the most affected region. In those with foot deformity, approximately 60% are in the tarsometatarsal joints (medial joints affected more than lateral), 30% Metatarsophalangeal joints and 10% have ankle disease. Over half of diabetic patients with neuropathic joints can recall some kind of precipitating trauma, usually, minor.

Patients with neurosyphilis tend to have knee involvement, and patients with syringomyelia of the spinal cord may demonstrate shoulder deformity.

Hip joint destruction is also seen in neuropathic patients.

Clinical FindingsEdit

Clinical findings include erythema, edema and increased temperature in the affected joint. In neuropathic foot joints, plantar ulcers may be present. Note that it is often difficult to differentiate osteomyelitis from a Charcot joint, as they may have similar tagged WBC scan and MRI features (joint destruction, dislocation, edema). Definitive diagnosis may require bone or synovial biopsy.

Radiologic FindingsEdit

First, it is important to recognize that two types of abnormality may be detected. One is termed atrophic, in which there is osteolysis of the distal metatarsals in the forefoot. The more common form of destruction is hypertrophic joint disease, characterized by acute peri-articular fracture and joint dislocation. According to Yochum and Rowe, the "6 D's" of hypertrophy are:

  1. Distended joint
  2. Density increase
  3. Debris production
  4. Dislocation
  5. Disorganization
  6. Destruction

The natural history of the joint destruction process has a classification scheme of its own, offered by Eichenholtz decades ago:

Stage 0: Clinically, there is joint edema, but radiographs are negative. Note that a bone scan may be positive before a radiograph is, making it a sensitive but not very specific modality.

Stage 1: Osseous fragmentation with joint dislocation seen on radiograph ("acute Charcot").

Stage 2: Decreased local edema, with coalescence of fragments and absorption of fine bone debris

Stage 3: No local edema, with consolidation and remodeling (albeit deformed) of fracture fragments. The foot is now stable.

Destroyed Tarsometatarsal joints in the medial left foot, with fracture and dislocation of fragments; these are classic findings. Also note loss of the foot arch and acquired flat foot (pes planus) deformity.

Atrophic Features:

  1. "Licked candy stick" appearance, commonly seen at the distal aspect of the metatarsals
  2. Diabetic osteolysis
  3. Bone resorption

TreatmentEdit

Once the process is recognized, immobilization with a total contact cast will help ward off further joint destruction. Pneumatic walking braces are also used. Surgical correction of a joint is rarely successful in the long-term in these patients.

It can take 6–9 months for the edema and erythema of the affected joint to recede.

ReferencesEdit

  • Neuropathic osteoarthropathy by Monica Bhargava, M.D., University of Washington Department of Radiology
  • John R. Crockarell; Daugherty, Kay; Jones, Linda Winstead; Frederick M. Azar; Beaty, James H; James H. Calandruccio; Peter G. Carnesale; Kevin B. Cleveland; Andrew H. Crenshaw (2003). Campbell's Operative Orthopedics, 10th, Saint Louis: C.V. Mosby.
  • Gupta R (November 1993). A short history of neuropathic arthropathy. Clin. Orthop. Relat. Res. (296): 43–9.
  • Sommer TC, Lee TH (November 2001). Charcot foot: the diagnostic dilemma. Am Fam Physician 64 (9): 1591–8.


Diabetes mellitus
Types of Diabetes
Diabetes mellitus type 1
Diabetes mellitus type 2
Gestational diabetes

Prediabetes:
Impaired fasting glycaemia
Impaired glucose tolerance

Disease Management
Diabetes management:
Diabetic diet
Anti-diabetic drugs
Conventional insulinotherapy
Intensive insulinotherapy
Other Concerns
Cardiovascular disease

Diabetic comas:
Diabetic hypoglycemia
Diabetic ketoacidosis
Nonketotic hyperosmolar

Diabetic myonecrosis
Diabetic nephropathy
Diabetic neuropathy
Diabetic retinopathy

Diabetes and pregnancy

Blood tests
Fructosamine
Glucose tolerance test
Glycosylated hemoglobin


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