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The neuromedin B receptor (NMBR), now known as BB1 [1] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[2] is on of the neuromedin receptors.

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[3]

See alsoEdit


  1. Bombesin Receptors: BB1. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  2. Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). Expression and characterization of cloned human bombesin receptors. Mol. Pharmacol. 47 (1): 10–20.
  3. Entrez Gene: NMBR neuromedin B receptor.

Further readingEdit

  • Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.. J. Biol. Chem. 266 (28): 18771–9.
  • Wu JM, Hoang DO, Feldman RI (1995). Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs.. Mol. Pharmacol. 47 (4): 871–81.
  • Benya RV, Kusui T, Pradhan TK, et al. (1995). Expression and characterization of cloned human bombesin receptors.. Mol. Pharmacol. 47 (1): 10–20.
  • Bitar KN, Zhu XX (1994). Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction.. Gastroenterology 105 (6): 1672–80.
  • Giladi E, Nagalla SR, Spindel ER (1993). Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.. J. Mol. Neurosci. 4 (1): 41–54.
  • Fathi Z, Benya RV, Shapira H, et al. (1993). The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding.. J. Biol. Chem. 268 (20): 14622–6.
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). Bombesin-like peptide receptors in human bronchial epithelial cells.. Peptides 17 (1): 111–8.
  • Sainz E, Akeson M, Mantey SA, et al. (1998). Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.. J. Biol. Chem. 273 (26): 15927–32.
  • Lee S, Kim Y (1999). Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy.. FEBS Lett. 460 (2): 263–9.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
  • Matusiak D, Glover S, Nathaniel R, et al. (2005). Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon.. Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28.

External linksEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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