Fandom

Psychology Wiki

Neurexins

Redirected from Neurexin

34,202pages on
this wiki
Add New Page
Talk0 Share

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


A neurexin (NRXN) is a presynaptic protein that helps to glue together neurons at the synapse.[1] Neurexins are type I membrane proteins that can be classified into two types, α-NRXNs and β-NRXNs. The α-NRXNs are larger and have different amino-terminal extracellular sequences. Neurexins mediate signaling across the synapse, and affect the properties of neural networks by specifying synaptic functions. In humans, alterations in genes encoding neurexins are implicated in autism and other cognitive diseases.[2]

Neurexins were discovered as receptors for α-latrotoxin, a toxin in black widow spider venom.[2] Their functional roles in insects are likely similar to those in vertebrates.[3]

β-Neurexins (located presynaptically) act as receptors for neuroligin (located postsynaptically). Neurexin and neuroligin "shake hands," resulting in the connection between the two neurons and the production of a synapse.[4] Additionally, β-Neurexin has also been found to play a role in angiogenesis.[5]

The neurexin genes are NRXN1, NRXN2, and NRXN3.[2]

See also Edit

References Edit

  1. Li X, Zhang J, Cao Z, Wu J, Shi Y (2006). Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin. Protein Sci. 15 (9): 2149–58.
  2. 2.0 2.1 2.2 Südhof TC (2008). Neuroligins and neurexins link synaptic function to cognitive disease. Nature 455 (7215): 903–11.
  3. Biswas S, Russell RJ, Jackson CJ et al. (2008). Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera. PLoS ONE 3 (10): e3542.
  4. Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (2000) (2000). Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons. Cell 101 (6): 657–669.
  5. Bottos A, Destro E, Rissone A, Graziano S, Cordara G, Assenzio B, Cera MR, Mascia L, Bussolino F, Arese M. (2009). The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions. Proc Natl Acad Sci U S A. 106:20782–20787. DOI:10.1073/pnas.0809510106 PMID 19926856


This page uses Creative Commons Licensed content from Wikipedia (view authors).

Also on Fandom

Random Wiki