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Neural transplantation

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Neural transplantation is the attempt to transplant neurons in an attempt to improve a number of nervous system disorders, including paralysis, Parkinson's disease etc


In parkinsons disease the first prospective randomised double-blind sham-placebo controlled trial of dopamine-producing cell transplants failed to show an improvement in quality of life although some significant clinical improvements were seen in patients below the age of 60.[1] A significant problem was the excess release of dopamine by the transplanted tissue, leading to dystonias.[2] Research in African green monkeys suggests that the use of stem cells might in future provide a similar benefit without inducing dystonias.[3]

See alsoEdit

ReverencesEdit

  1. Freed CR, Greene PE, Breeze RE, et al (2001). Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344 (10): 710–9.
  2. Redmond DE (2002). Cellular replacement therapy for Parkinson's disease--where we are today?. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 8 (5): 457–88.
  3. Redmond E et al (2007). Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences 104 (29): 12175.

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