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The National Institute for Health and Clinical Excellence or NICE is an agency of the National Health Service in the United Kingdom. It was set up in 1999 to defuse the postcode lottery system of healthcare in England and Wales, where treatments that were available depended upon which NHS Trust area in which the patient lived. It publishes clinical appraisals, of whether particular treatments should be considered worthwhile by the NHS (cost effective).

On 1 April 2005 NICE joined with the Health Development Agency to become the new National Institute for Health and Clinical Excellence (also to be known as NICE and formerly known as "National Institute for Clinical Excellence").

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