N-Arachidonoyl dopamine

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

N-Arachidonoyl dopamine
N-Arachidonoyl dopamine
General
Systematic name	?
Other names	?
Molecular formula	?
SMILES	?
Molar mass	?.?? g/mol
Appearance	?
CAS number	[?-?-?]
Properties
Density and phase	? g/cm³, ?
Solubility in water	? g/100 ml (?°C)
Melting point	?°C (? K)
Boiling point	?°C (? K)
Acidity (pK_a)	?
Basicity (pK_b)	?
Chiral rotation [α]_D	?°
Viscosity	? cP at ?°C
Structure
Molecular shape	?
Coordination geometry	?
Crystal structure	?
Dipole moment	? D
Hazards
MSDS	External MSDS
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NFPA 704
Flash point	?°C
R/S statement	R: ? S: ?
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Supplementary data page
Structure and properties	n, ε_r, etc.
Thermodynamic data	Phase behaviour Solid, liquid, gas
Spectral data	UV, IR, NMR, MS
Related compounds
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

N-Arachidonoyl dopamine (NADA) is an endocannabinoid that acts as an agonist of the CB₁ receptor^[1] and the transient receptor potential V1 (TRPV1) ion channel. Its discovery was described in 2002 by an academic research group from Italy and the USA. It was found in the brain of rats, with especially high concentrations in the hippocampus, cerebellum, and striatum. It activates the TRPV1 channel with an EC₅₀ of approximately of 50nM. The high potency makes it the putative endogenous TRPV1 agonist.^[2]

References[]

↑ Ralevic V (July 2003). Cannabinoid modulation of peripheral autonomic and sensory neurotransmission. European Journal of Pharmacology 472 (1–2): 1–21.
↑ Huang SM, Bisogno T, Trevisani M, Al-Hayani A, De Petrocellis L, Fezza F, Tognetto M, Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V (June 2002). An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proceedings of the National Academy of Sciences of the United States of America 99 (12): 8400–5.

Cannabinoids edit
{Anandamide} {CBD} {CBDV} {CBN} {CBV} {CP 55,940} {HU-210} {Nabilone} {Rimonabant} {THC} {THCV} {WIN 55,212-2} {URB597}

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