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Muscimol

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Template:Chembox SolubilityTemplate:Chembox SolubilityTemplate:Chembox Solubility
style="background: #F8EABA; text-align: center;" colspan="2" Muscimol
170px
150px
Molecular formula C4H6N2O2
Identifiers
CAS number 18174-72-6
SMILES NCc1cc(O)no1
Properties
Molar mass 114.10 g/mol
Melting point

184-185°C

Hazards
style="background: #F8EABA; text-align: center;" colspan="2" Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Muscimol (Agarin, Pantherine) is the major psychoactive alkaloid present in many mushrooms of the Amanita genus. Unlike psilocybin, a tryptamine, muscimol is a potent, selective agonist of the GABAA receptor.

ChemistryEdit

Muscimol is the product of the decarboxylation or drying of ibotenic acid.

Biology Edit

File:Amanita muscaria 2.jpg

Muscimol is produced naturally in the mushrooms Amanita muscaria, Amanita pantherina, and Amanita gemmata, along with muscarine, muscazone, and ibotenic acid. Of these, only A. muscaria and A. pantherina are considered somewhat safe for human consumption, with the other being far more dangerous; however lethal poisonings have occurred from A. muscaria and A. pantherina as well.[1],[2] It is thought that[attribution needed], in A. muscaria, the layer just below the skin of the cap contains the highest amount of muscimol, and is therefore the most psychoactive portion.

Pharmacology Edit

Muscimol is a potent GABAA agonist, which is a receptor for the brain's major inhibitory neurotransmitter, GABA. The primary use for muscimol has become lab research, as the chemical essentially "turns off" part of the brain.[How to reference and link to summary or text] When muscimol is administered, it has been shown active in the cerebral cortex, hippocampus, and cerebellum.

During a test involving rabbits connected to an EEG, muscimol showed a distinctly synchronized EEG tracing. This is substantially different from indolic psychedelics, as brainwave patterns will generally show a desynchronization. In higher doses (2mg/kg), the EEG will show characteristic spikes.

When used in vivo, muscimol will pass through the human body, and be excreted (as muscimol) in the subject's urine.

The psychoactive dose of muscimol is around 15-20mg for a normal person[How to reference and link to summary or text].

Toxicity Edit

LD50 mice: 3.8 mg/kg s.c, 2.5 mg/kg i.p.[1]

LD50 rats: 4.5 mg/kg i.v, 45 mg/kg orally.[1]

Effects Edit

The effects of muscimol are substantially different from psilocybin, as the chemicals target separate parts of the brain. Muscimol has been shown to lack "structured" hallucinations in most cases, and the effects are frequently compared to a lucid dream state.

See also Edit

External links Edit

References Edit

  1. 1.0 1.1 Erowid Psychoactive Amanitas Vault : Chemistry
  • Merck Index, 12th Edition
  • Ito Y, Segawa K, Fukuda H. 1995 "Functional diversity of GABAA receptor ligand-gated chloride channels in rat synaptoneurosomes" Synapse 19(3):188-96.
  • Rätsch, Christian. (1998). The Encyclopedia of Psychoactive Plants. Rochester, VT: Park Street Press.
  • Beaumont K, Chilton W. S., Yamamura H. I., Enna S. J. (1978). Muscimol binding in rat brain: association with synaptic GABA receptors.. Brain Res. 148 (1): 153-62.
  • S. R. Snodgrass (1978). Use of 3H-muscimol for GABA receptor studies. Nature 273 (1): 392 - 394.
  • G. A. R. Johnston, D. R. Curtis, W. C. de Groat and A. W. Duggan (1968). Central actions of ibotenic acid and muscimol. Biochemical Pharmacology 17 (12): 2488-2489.


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