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Individual differences |
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The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor.
The M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system, by slowing the speed of depolarization. They also reduce contractile forces of the atrial cardiac muscle, and reduce conduction velocity of the atrioventricular node (AV node). However, they have no effect on the contractile forces of the ventricular muscle.
M2 muscarinic receptors act via a Gi type receptor, which causes a decrease in cAMP in the cell, generally leading to inhibitory-type effects.
Multiple alternatively spliced transcript variants have been described for this gene.
- ↑ Rang, H. P. (2003). Pharmacology, Edinburgh: Churchill Livingstone.
- ↑ Boron, W. F and Boulpaep, E. L. (2005). Medical Physiology, 387, Philadelphia: Elsevier Saunders.
- ↑ 3.0 3.1 Entrez Gene: CHRM2 cholinergic receptor, muscarinic 2.
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- Acetylcholine receptors (muscarinic): M2. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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