Changes: Molindone

Latest revision as of 07:37, 23 January 2009

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

Molindone chemical structure Molindone
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)- 1,5,6,7-tetrahydro-4H-indol-4-one IUPAC name
CAS number 7416-34-4	ATC code N05 AE02
PubChem 23897	DrugBank [1]
Chemical formula	{{{chemical_formula}}}
Molecular weight	276.374 g/mol
Bioavailability
Metabolism	Hepatic
Elimination half-life	1.5 hours
Excretion	Minor, renal and fecal
Pregnancy category
Legal status
Routes of administration	Oral

Molindone is a therapeutic antipsychotic, used in the treatment of schizophrenia.^[1] It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken by mouth.

Molindone is sold under the product name Moban.

Adverse effects

Main article: Typical antipsychotic

The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.^[2]^[3]

References

↑ molindone. (web) F.A. Davis Company. URL accessed on 2007-11-04.
↑ Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). Molindone for schizophrenia and severe mental illness. Cochrane Database Syst Rev (1): CD002083.
↑ Allison DB, Mentore JL, Heo M, et al (1999). Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156 (11): 1686–96. Free full text

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[1] . (web) F.A. Davis Company. URL accessed on 2007-11-04.

[Bagnall-2] Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). Molindone for schizophrenia and severe mental illness. Cochrane Database Syst Rev (1): CD002083.

[3] Allison DB, Mentore JL, Heo M, et al (1999). Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156 (11): 1686–96. Free full text

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[2]

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@@ Line 1: / Line 1: @@
 {{BioPsy}}
+{{drugbox |
-'''Molindone''' is a therapeutic [[antipsychotic]], used in the treatment of [[Schizophrenia]]. <ref>{{cite web
+| IUPAC_name = 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-<br>1,5,6,7-tetrahydro-4''H''-indol-4-one
+| image = Molindone.svg
+| CAS_number = 7416-34-4
+| ATC_prefix = N05
+| ATC_suffix = AE02
+| PubChem = 23897
+| DrugBank =
+| C = 16 | H = 24 | N = 2 | O = 2
+| molecular_weight = 276.374 g/mol
+| smiles = CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C
+| bioavailability =
+| protein_bound =
+| metabolism = [[Liver|Hepatic]]
+| elimination_half-life = 1.5 hours
+| excretion = Minor, [[kidney|renal]] and fecal
+| pregnancy_AU =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = C
+| pregnancy_category =
+| legal_AU =  <!-- Unscheduled / S2 / S3 / S4  / S8 -->
+| legal_CA =  <!--                             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_UK =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| legal_US = Rx-only
+| legal_status =
+| routes_of_administration = Oral
+}}
+'''Molindone''' is a therapeutic [[antipsychotic]], used in the treatment of [[schizophrenia]].<ref>{{cite web
   | last =
   | first =
@@ Line 12: / Line 38: @@
   | format = web
   | doi =
-  | accessdate = January 21, 2007 }}</ref> It works by blocking the effects of [[dopamine]] in the brain, leading to diminished psychoses.  It is rapidly absorbed when take by mouth.
+  | accessdate = 2007-11-04}}</ref> It works by blocking the effects of [[dopamine]] in the brain, leading to diminished psychoses.  It is rapidly absorbed when taken by mouth.
+Molindone is sold under the product name Moban.
+<!--  Commented out because image was deleted: [[Image:MobanAd.png|thumb|300px|left|Advertisement, 1982.]] -->
+==Adverse effects==
+{{main|Typical antipsychotic}}
+The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.<ref name=Bagnall>{{cite journal |author=Bagnall A, Fenton M, Kleijnen J, Lewis R |title=Molindone for schizophrenia and severe mental illness |journal=Cochrane Database Syst Rev |volume= |issue=1 |pages=CD002083 |year=2007 |pmid=17253473 |doi=10.1002/14651858.CD002083.pub2}}</ref><ref>{{cite journal |author=Allison DB, Mentore JL, Heo M, ''et al'' |title=Antipsychotic-induced weight gain: a comprehensive research synthesis |journal=[[American Journal of Psychiatry|Am J Psychiatry]] |volume=156 |issue=11 |pages=1686–96 |year=1999 |pmid=10553730 |doi=}} [http://ajp.psychiatryonline.org/cgi/content/full/156/11/1686 Free full text]</ref>
 ==See also==
@@ Line 24: / Line 57: @@
+[[Category:Antidepressant drugs]]
+[[Category:Neuroleptic drugs]]
+[[Category:Sedatives]]
+[[Category:Serotonin agonists]]
 [[Category:Typical antipsychotics]]
+<!--
+[[sv:Molindon]]
+[[ru:Молиндон]]
+-->
 {{enWP|Molindone}}

This box: view • talk • edit Psycholeptics: antipsychotics (N05A)
Phenothiazine typical antipsychotics	Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine
Other typical antipsychotics	Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine)
Atypical antipsychotics	Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine)