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Micropolygyria

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Micropolygyria also known as polygyria or microgyria is a Neuronal migration disorder, a developmental anomaly of the brain characterized by development of numerous small convolutions (microgyri), causing intellectual disabilities.[1] It is present in a number of specific neurological diseases, notably multiple sclerosis and Fukuyama congenital muscular dystrophy, a specific disease cause by mutation in the Fukutin gene (FKTN).[2][3]

ReferencesEdit

  1. Dorland's Illustrated Medical Dictionary Merck.
  2. Murakami T, Hayashi YK, Noguchi S, et al. (November 2006). Fukutin gene mutations cause dilated cardiomyopathy with minimal muscle weakness. Ann. Neurol. 60 (5): 597–602.
  3. Brockington M, Blake DJ, Prandini P, et al. (December 2001). Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan. Am. J. Hum. Genet. 69 (6): 1198–209.
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