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Micropolygyria also known as polygyria or microgyria is a Neuronal migration disorder, a developmental anomaly of the brain characterized by development of numerous small convolutions (microgyri), causing intellectual disabilities.[1] It is present in a number of specific neurological diseases, notably multiple sclerosis and Fukuyama congenital muscular dystrophy, a specific disease cause by mutation in the Fukutin gene (FKTN).[2][3]


  1. Dorland's Illustrated Medical Dictionary Merck.
  2. Murakami T, Hayashi YK, Noguchi S, et al. (November 2006). Fukutin gene mutations cause dilated cardiomyopathy with minimal muscle weakness. Ann. Neurol. 60 (5): 597–602.
  3. Brockington M, Blake DJ, Prandini P, et al. (December 2001). Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan. Am. J. Hum. Genet. 69 (6): 1198–209.
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