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Metirosine

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Metirosine chemical structure
Metirosine

(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
IUPAC name
CAS number
672-87-7
ATC code

C02KB01

PubChem
10123
DrugBank
[1]
Chemical formula {{{chemical_formula}}}
Molecular weight 195.215 g/mol
Bioavailability
Metabolism
Elimination half-life 3.4–3.7 hours
Excretion {{{excretion}}}
Pregnancy category
Legal status
Routes of administration

Metirosine (α-Methyltyrosine, Metyrosine, AMPT) is an antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which consequently depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body.

Clinical useEdit

Metirosine has been used in the treatment of phaeochromocytoma.[1] It is contra-indicated for the treatment of essential hypertension.

However it is now rarely used in medicine, and its main use is in scientific research, to investigate the effects of catecholamine depletion on behaviour.[2]

See alsoEdit

ReferencesEdit

  1. Green KN, Larsson SK, Beevers DG, Bevan PG, Hayes B (August 1982). Alpha-methyltyrosine in the management of phaeochromocytoma. Thorax 37 (8): 632–3.
  2. O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berlin). 2007 Jun;192(3):357-71. PMID 17318507

Template:Antihypertensives and diuretics

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