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Methohexital

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Methohexital chemical structure
Methohexital

5-hex-3-yn-2-yl-1- methyl-5-prop-2-enyl-1, 3-diazinane-2,4,6-trione
IUPAC name
CAS number
151-83-7
ATC code

N01AF01 .

PubChem
9034
DrugBank
APRD00058
Chemical formula {{{chemical_formula}}}
Molecular weight 262.304
Bioavailability I.V. ~100%
Rectal ~17%
Metabolism Hepatic
Elimination half-life 5.6 ± 2.7 minutes
Excretion  ?
Pregnancy category B (USA)
Legal status  ?
Routes of administration Intravenous, rectal

Methohexital (marketed under the brand name Brevital) is a drug which is a barbiturate derivative.[citation needed] It is classified as short-acting, and has a rapid onset of action. It is similar in its effects to sodium thiopental, a drug with which it competed in the market for anaesthetics.

PharmacologyEdit

Methohexital binds to a distinct site which is associated with Cl ionophores at GABAA receptors.[citation needed] This increases the length of time which the Cl ionopores are open, thus causing an inhibitory effect.

Metabolism of methohexital is primarily hepatic (i.e., taking place in the liver) via demethylation and oxidation.[citation needed] Side-chain oxidation is the primary means of metabolism involved in the termination of the drug's biological activity.

Protein binding is approximately 73% for methohexital.[citation needed]

IndicationsEdit

Methohexital is primarily used to induce anesthesia, and is generally provided as a sodium salt (i.e. methohexital sodium). It is only used in hospital or ambulatory care (i.e. in an ambulance) settings, under strict supervision.[citation needed] It has been commonly used to induce deep sedation, "twilight sleep" or general anesthesia for oral surgery and dentistry. It is also used to induce anesthesia prior to ECT(electroconvulsive therapy).

External linksEdit


Barbiturates edit

Allobarbital, Amobarbital, Aprobarbital, Barbexaclone, Barbital, Butabarbital, Butalbital, Butobarbital, Cyclobarbital, Ethallobarbital, Heptabarbital, Hexobarbital, Mephobarbital, Metharbital, Methohexital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone, Proxibarbal, Reposal, Secobarbital, Talbutal, Thiobarbital, Thiopental, Vinbarbital, Vinylbital


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