Mesoridazine
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Mesoridazine chemical structure | |
| 10-{2-[(RS)1-Methylpiperidin-2-yl]ethyl}-2-methylsulfinyl-10H-phenothiazine IUPAC name | |
| CAS number 5588-33-0 | ATC code |
| PubChem 4078 | DrugBank APRD00610 |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 386.576 g/mol |
| Bioavailability | |
| Metabolism | Hepatic/Renal |
| Elimination half-life | 24 to 48 hours |
| Excretion | Biliary/Renal |
| Pregnancy category | C (USA) |
| Legal status | Rx-only |
| Routes of administration | oral, intravenous |
Mesoridazine besylate (trade name Serentil) is a neuroleptic drug that is used in the treatment of schizophrenia, organic brain disorders, psychoneuroses, and alcoholism. It is the besylate salt of a metabolite of thioridazine. It exerts its actions through a central adrenergic-blocking, a dopamine-blocking, a serotonin-blocking, and a weak anticholinergic action. It also exerts part of its actions through depression of hypothalamic centers, like other phenothiazines.
It was withdrawn from the United States market in 2004.
Psycholeptics: antipsychotics (N05A)
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|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine) |
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