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Mesoridazine chemical structure | |
| 10-{2-[(RS)1-Methylpiperidin-2-yl]ethyl}-2-methylsulfinyl-10H-phenothiazine IUPAC name | |
| CAS number 5588-33-0 | ATC code |
| PubChem 4078 | DrugBank APRD00610 |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 386.576 g/mol |
| Bioavailability | |
| Metabolism | Hepatic/Renal |
| Elimination half-life | 24 to 48 hours |
| Excretion | Biliary/Renal |
| Pregnancy category | C (USA) |
| Legal status | Rx-only |
| Routes of administration | oral, intravenous |
Mesoridazine besylate (trade name Serentil) is a neuroleptic drug that is used in the treatment of schizophrenia, organic brain disorders, psychoneuroses, and alcoholism. It is the besylate salt of a metabolite of thioridazine. It exerts its actions through a central adrenergic-blocking, a dopamine-blocking, a serotonin-blocking, and a weak anticholinergic action. It also exerts part of its actions through depression of hypothalamic centers, like other phenothiazines.
It was withdrawn from the United States market in 2004.
See also
Edit
Psycholeptics: antipsychotics (N05A)
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|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine) |
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