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In both the male and the female the Wolffian duct develops into the trigone of urinary bladder, a part of the bladder wall. However, further development differentiates between the sexes in the development of the urinary and reproductive organs.
In a male, it develops into a system of connected organs between the efferent ducts of the testis and the prostate, namely the epididymis, the vas deferens, and the seminal vesicle. The prostate forms from the urogenital sinus and the efferent ducts form from the mesonephric tubules.
For this it is critical that the ducts are exposed to testosterone during embryogenesis. Testosterone binds to and activates androgen receptor, affecting intracellular signals and modifying the expression of numerous genes.
In the female, in the absence of testosterone support, the Wolffian duct regresses, and inclusions may persist. The epoophoron and Skene's glands may be present. Also, lateral to the wall of the vagina a Gartner's duct or cyst could develop as a remnant.
See also Edit
- Fetal genital development
- List of homologues of the human reproductive system
- Müllerian duct
- Sexual differentiation
- Wolffian system
- Wolffian tubules
- Wolffian structures
- ↑ Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA (2006). Changes in gene expression during Wolffian duct development. Horm. Res. 65 (4): 200–9.
- ↑ Wolffian duct: Derivatives. LifeHugger. URL accessed on 2009-12-12.
- ↑ Who Named It synd/2845
- How the Body Works / Sex Development / Sexual Differentiation / Duct Differentiation - The Hospital for Sick Children (GTA - Toronto, Ontario, Canada)
Prenatal development/mammalian embryogenesis - Development of the urinary and reproductive organs
|General Urinary/Reproductive system|
|Fetal genital development - primarily internal|