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Mesial temporal sclerosis

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Mesial Temporal Sclerosis
ICD-10 {{{ICD10}}}
ICD-9 {{{ICD9}}}
OMIM {{{OMIM}}}
DiseasesDB 34097
MedlinePlus {{{MedlinePlus}}}
eMedicine {{{eMedicineSubj}}}/{{{eMedicineTopic}}}
MeSH {{{MeshNumber}}}


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Mesial temporal sclerosis is a specific pattern of hippocampal neuron cell loss[1] [2]. There are 3 specific patterns of cell loss; Cell loss might involve sectors CA1 and CA4, CA4 alone, or CA1 to CA4 [3]. Associated hippocampal atrophy and gliosis is common[4]. MRI scan commonly displays increased T2 signal and hippocampal atrophy [5] Mesial temporal sclerosis might occur with other temporal lobe abnormalities (dual pathology) [6]. Mesial temporal sclerosis is the most common pathological abnormality in temporal lobe epilepsy[7] [8].

See alsoEdit

Notes Edit

  1. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  2. Trepeta, Scott 2007
  3. Trepeta, Scott 2007
  4. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  5. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  6. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  7. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  8. Trepeta, Scott 2007

References Edit

  • Bronen RA, Fulbright RK, Spencer DD, et al. Refractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients. Radiology. Oct 1996;201(1):97-105
  • Trepeta, Scott. "eMedicine - Mesial Temporal Sclerosis." 11 Sept. 2007. Jamaica Hospital. 9 Apr. 2008 <http://www.emedicine.com/radio/topic443.htm>

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