Wikia

Psychology Wiki

Merkel cells

Talk0
34,117pages on
this wiki

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


Merkel cells are oval receptor cells found in the skin of vertebrates. They are associated with the sense of light touch and are responsible for the highly malignant skin tumor known as Merkel cell carcinoma.

There is evidence that they are derived from neural crest.[1]

HistoryEdit

They were named after the 19th century German anatomist Friedrich Sigmund Merkel who was the first to fully describe them in 1872.

LocationEdit

Merkel cells are found in the skin and some parts of the mucosa (stratum germinativum) of all vertebrates. In mammalian skin, they are clear cells found in the stratum basale (at the bottom of sweat duct ridges)of the epidermis approximately 10 µm in diameter. Most often, they are associated with sensory nerve endings, when they are known as Merkel nerve endings. They are associated with Rapidly Adapting (RA) nerve fibers.

FunctionEdit

The exact function of Merkel cells is unclear. F.S. Merkel referred to them as Tastzellen or "touch cells", although their function has been disputed ever since. Merkel cells are sometimes considered APUD cells because they contain dense core granules, and thus may have a neuroendocrine function.

Developmental originEdit

The origin of Merkel cells is still debated. Evidence from skin graft experiments in birds implies that they are neural crest derived, while experiments in mammals generally point to an epidermal origin.

See alsoEdit


ReferencesEdit

  1. (2003) The Merkel cell: structure-development-function- cancerogenesis, 99–, Springer. URL accessed 2 May 2010.

External linksEdit


Nervous system - Sensory system - edit
Special sensesVisual system | Auditory system | Olfactory system | Gustatory system
Somatosensory systemNociception | Thermoreception | Vestibular system |
Mechanoreception (Pressure, Vibration & Proprioception) | Equilibrioception 





This page uses Creative Commons Licensed content from Wikipedia (view authors).

Around Wikia's network

Random Wiki