Mendelian Inheritance in Man
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The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. It is available as a book titled Mendelian Inheritance in Man (MIM), which is currently in its 12th edition.
The online version is called Online Mendelian Inheritance in Man (OMIM), which can be accessed with the Entrez database searcher of the National Library of Medicine.
OMIM™ and Online Mendelian Inheritance in Man™ are trademarks of the Johns Hopkins University.
Contents |
[edit] Collection process
The information in this database is collected and processed under the leadership of Dr. Victor A. McKusick at Johns Hopkins University, assisted by a team of science writers and editors. Relevant articles are identified, discussed and written up in the relevant entries in the MIM database
[edit] The MIM code
Every disease and gene is assigned a six digit number of which the first number classifies the method of inheritance.
If the initial digit is 1, the trait is deemed autosomal dominant; if 2, autosomal recessive; if 3, X-linked. Wherever a trait defined in this dictionary has a MIM number, the number from the 12th edition of MIM, is given in square brackets with or without an asterisk (asterisks indicate that the mode of inheritance is known; a number symbol (#) before an entry number means that the phenotype can be caused by mutation in any of 2 or more genes) as appropriate e.g., Pelizaeus-Merzbacher disease [MIM*169500] is a well-established, autosomal, dominant, mendelian disorder.
| First Digit | Range of MIM codes | Method of inheritance |
| 1 | 100000-199999 | Autosomal dominant loci or phenotypes (created before May 15, 1994) |
| 2 | 200000-299999 | Autosomal recessive loci or phenotypes (created before May 15, 1994) |
| 3 | 300000-399999 | X-linked loci or phenotypes |
| 4 | 400000-499999 | Y-linked loci or phenotypes |
| 5 | 500000-599999 | Mitochondrial loci or phenotypes |
| 6 | 600000- | Autosomal loci or phenotypes (created after May 15, 1994) |
[edit] References
- Table from the OMIM FAQ
- McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders. Baltimore, MD: The Johns Hopkins University Press, 1998. ISBN 0-8018-5742-2.
[edit] See also
[edit] External link
- Online Mendelian Inheritance in Man (to search OMIM)
| Databases supported by Bioinformatic Harvester |
| UniProt | SOURCE | SMART | SOSUI | PSORT | HomoloGene | GFP-cDNA | IPI | OMIM NCBI-BLAST | Genome-Browser | Ensembl | RZPD | STRING | iHOP | Entrez |
es:Herencia Mendeliana en el Hombre fr:Héritage mendélien chez l'Homme he:OMIM hu:Mendeli öröklődés emberben adatbázis pt:Online Mendelian Inheritance in Man zh:人類孟德爾遺傳學
| This page uses content from the English-language version of Wikipedia. The original article was at Mendelian Inheritance in Man. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
