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Melperone

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Melperone chemical structure
Melperone

1-(4-fluorophenyl)-4-(4-methyl-1-piperidyl)butan-1-one
IUPAC name
CAS number
3575-80-2
ATC code

N05AD03

PubChem
15387
DrugBank
[1]
Chemical formula {{{chemical_formula}}}
Molecular weight 263.35 g/mol
Bioavailability
Metabolism Hepatic (inhibits CYP2D6[1])
Elimination half-life 3–4 hours (oral)
6 hours (IM)
Excretion
Pregnancy category
Legal status
Routes of administration Oral, intramuscular injection

Melperone (INN, also known as methylperone) is a butyrophenone atypical antipsychotic. It is sold under the trade names Buronil, Burnil, and Eunerpan.

ChemistryEdit

  • Molecular Formula: C16H23ClFNO
  • Molecular Weight: 299.82
  • Chemical Class: Butyrophenone
  • Pharmacological Class: Atypical antipsychotic
  • Appearance: White, crystalline odorless powder
  • Solubility: Free soluble in water. Freely soluble in ethanol 99.5% and chloroform. Practically insoluble in diethyl ether.
  • Melting Point: 205-210C
  • pH (1% in water): 4.5-6.5
  • Stability: 48 months

It is a white crystalline powder that is manufactured by Dupont Chemoswed (Sweden). It is a butyrophenone (1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride).

ReferencesEdit

  1. Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S (2003). Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. Pharmacopsychiatry 36 (1): 3–6.

External linksEdit



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