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{{BioPsy}}
 
{{BioPsy}}
{{protein
 
| Name = melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
 
| caption =
 
| image =
 
| width =
 
| HGNCid = 6929
 
| Symbol = MC1R
 
| AltSymbols =
 
| EntrezGene = 4157
 
| OMIM = 155555
 
| RefSeq = NM_002386
 
| UniProt = Q01726
 
| PDB =
 
| ECnumber =
 
| Chromosome = 16
 
| Arm = q
 
| Band = 24.3
 
| LocusSupplementaryData =
 
}}
 
{{protein
 
| Name = melanocortin 2 receptor (adrenocorticotropic hormone)
 
| caption =
 
| image =
 
| width =
 
| HGNCid = 6930
 
| Symbol = MC2R
 
| AltSymbols =
 
| EntrezGene = 4158
 
| OMIM = 607397
 
| RefSeq = NM_000529
 
| UniProt = Q01718
 
| PDB =
 
| ECnumber =
 
| Chromosome = 18
 
| Arm = p
 
| Band = 11.2
 
| LocusSupplementaryData =
 
}}
 
{{protein
 
| Name = melanocortin 3 receptor
 
| caption =
 
| image =
 
| width =
 
| HGNCid = 6931
 
| Symbol = MC3R
 
| AltSymbols =
 
| EntrezGene = 4159
 
| OMIM = 155540
 
| RefSeq = NM_019888
 
| UniProt = P41968
 
| PDB =
 
| ECnumber =
 
| Chromosome = 20
 
| Arm = q
 
| Band = 13.2
 
| LocusSupplementaryData = -13.3
 
}}
 
{{protein
 
| Name = melanocortin 4 receptor
 
| caption =
 
| image =
 
| width =
 
| HGNCid = 6932
 
| Symbol = MC4R
 
| AltSymbols =
 
| EntrezGene = 4160
 
| OMIM = 155541
 
| RefSeq = NM_005912
 
| UniProt = P32245
 
| PDB =
 
| ECnumber =
 
| Chromosome = 18
 
| Arm = q
 
| Band = 22
 
| LocusSupplementaryData =
 
}}
 
{{protein
 
| Name = melanocortin 5 receptor
 
| caption =
 
| image =
 
| width =
 
| HGNCid = 6933
 
| Symbol = MC5R
 
| AltSymbols =
 
| EntrezGene = 4161
 
| OMIM = 600042
 
| RefSeq = NM_005913
 
| UniProt = P33032
 
| PDB =
 
| ECnumber =
 
| Chromosome = 18
 
| Arm = p
 
| Band = 11.2
 
| LocusSupplementaryData =
 
}}
 
 
'''Melanocortin receptors''' are members of the [[rhodopsin]] family of 7-transmembrane, [[G-protein coupled receptors]].
 
'''Melanocortin receptors''' are members of the [[rhodopsin]] family of 7-transmembrane, [[G-protein coupled receptors]].
   
There are five members of the melanocortin receptor system each with differing specificities for [[melanocortin]]s.
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There are five members of the melanocortin receptor system<ref>[http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/bodyweight/melanocortins.html Melanocortins and the Melanocortin Receptor<!-- Bot generated title -->]</ref> each with differing specificities for [[melanocortin]]s:
   
MC2 is also known as the [[ACTH]] or corticotropin receptor because it is specific for ACTH alone.
+
* {{Gene|MC1R}}. [[Mc1r]] is associated with pigmentation genetics.
  +
* {{Gene|MC2R}}. It is also known as the [[ACTH receptor]] or corticotropin receptor because it is specific for ACTH alone.
  +
* {{Gene|MC3R}}
  +
* {{Gene|MC4R}}. Defects in MC4R are a cause of [[autosomal dominant]] [[obesity]], accounting for 6% of all cases of early-onset obesity.<ref>{{cite journal |author=Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S |title=Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene |journal=N. Engl. J. Med. |volume=348 |issue=12 |pages=1085-95 |year=2003 |pmid=12646665 |doi=10.1056/NEJMoa022050}}</ref>
  +
* {{Gene|MC5R}}
  +
These receptors are [[Receptor antagonist|inhibited]] by [[endogenous]] [[antagonists]] [[Agouti signalling peptide|agouti signaling protein]] and agouti-related protein<ref>{{cite journal |author=Chai B, Pogozheva I, Lai Y, Li J, Neubig R, Mosberg H, Gantz I |title=Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors |journal=Biochemistry |volume=44 |issue=9 |pages=3418-31 |year=2005 |pmid=15736952}}</ref> and activated by endogenous [[agonist]] [[melanocyte-stimulating hormone]].<ref>{{cite journal |author=Pogozheva I, Chai B, Lomize A, Fong T, Weinberg D, Nargund R, Mulholland M, Gantz I, Mosberg H |title=Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists |journal=Biochemistry |volume=44 |issue=34 |pages=11329-41 |year=2005 |pmid=16114870}}</ref>
  +
  +
==References==
  +
{{Reflist|2}}
   
 
==External links==
 
==External links==
  +
* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1290 IUPHAR GPCR Database - Melanocortin receptors]
 
* {{MeshName|Melanocortin+Receptors}}
 
* {{MeshName|Melanocortin+Receptors}}
  +
*[http://opm.phar.umich.edu/protein.php?pdbid=2iqv Calculated spatial position of melanocortin-4 receptor in the lipid bilayer, inactive state with antagonist] and [http://opm.phar.umich.edu/protein.php?pdbid=2iqr active state with agonist]
  +
  +
[[Category:G protein coupled receptors]]
  +
  +
{{G protein-coupled receptors}}
   
[[Category:Neroendocrinology]]
 
 
{{enWP|Melanocortin receptor}}
 
{{enWP|Melanocortin receptor}}

Latest revision as of 22:46, February 24, 2008

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Melanocortin receptors are members of the rhodopsin family of 7-transmembrane, G-protein coupled receptors.

There are five members of the melanocortin receptor system[1] each with differing specificities for melanocortins:

These receptors are inhibited by endogenous antagonists agouti signaling protein and agouti-related protein[3] and activated by endogenous agonist melanocyte-stimulating hormone.[4]

ReferencesEdit

  1. Melanocortins and the Melanocortin Receptor
  2. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S (2003). Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. 348 (12): 1085-95.
  3. Chai B, Pogozheva I, Lai Y, Li J, Neubig R, Mosberg H, Gantz I (2005). Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors. Biochemistry 44 (9): 3418-31.
  4. Pogozheva I, Chai B, Lomize A, Fong T, Weinberg D, Nargund R, Mulholland M, Gantz I, Mosberg H (2005). Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists. Biochemistry 44 (34): 11329-41.

External linksEdit


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