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Symbol(s): MDGA2 MAMDC1
Locus: 14 q21.2
EC number [1]
EntrezGene 161357
OMIM 611128
RefSeq NM_182830
UniProt [2]

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.

The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]

There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5]

References Edit

  1. MDGA2 Gene — GeneCards. Weizmann Institute of Science.
  2. Rat Genome Database: Mdga2 ( Rattus norvegicus ). Medical College of Wisconsin. URL accessed on 2008-11-14.
  3. E. David Litwack, Regis Babey, Reto Buser, Matthias Gesemann & Dennis D. M. O'Leary (February 2004). Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization. Molecular and Cellular Neurosciences 25 (2): 263–264.
  4. SNP linked to Gene MDGA2. NCBI.
  5. E. J. van den Oord, P. H. Kuo, A. M. Hartmann, B. T. Webb, H. J. Möller, J. M. Hettema, I. Giegling, J. Bukszár, D. Rujescu (September 2008). 18762592. Archives of General Psychiatry 65 (9): 1062–1071.
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