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Müllerian ducts

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Embryology: Müllerian ducts
Urogenital sinus of female human embryo of eight and a half to nine weeks old.
Tail end of human embryo, from eight and a half to nine weeks old.
Latin d. paramesonephricus
Gray's subject #252 1206
System
Carnegie stage 17
Days {{{Days}}}
Precursor Intermediate mesoderm
Gives rise to
MeSH A16.254.570
Dorlands/Elsevier d_29/12315002

The Müllerian ducts (or paramesonephric ducts) are paired ducts of the embryo which run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, it will develop to form the fallopian tubes, uterus, and the upper portion of the vagina. It is tissue of mesodermal origin.

Development

File:Gray1110.png

Müllerian duct develops in females and degenerates in males.

Regulation of development

The development of the Müllerian ducts is controlled by the presence or absence of "AMH", or Anti-müllerian hormone (also known as "MIF" for "Müllerian inhibiting factor", or "MIH" for "Müllerian inhibiting hormone").

male embryogenesis The testes produce AMH and as a result the development of the Müllerian ducts is inhibited. Disturbances can lead to persistent müllerian duct syndrome. The ducts disappear except for the vestigial vagina masculina and the appendix testis.
female embryogenesis The absence of AMH results in the development of female reproductive organs, as noted above. Disturbance in the development may result in uterine absence (Mullerian agenesis) or uterine malformations. The ducts develop into the upper vagina, cervix, uterus and oviducts.

Eponym

They are named after Johannes Peter Müller, a physiologist who described these ducts in his text "Bildungsgeschichte der Genitalien" in 1830.

Additional images

See also

External links


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