Loxapine
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[[Image:|150px|Loxapine chemical structure]] | |
| IUPAC name | |
| CAS number 1977-10-2 | ATC code |
| PubChem 3964 | DrugBank APRD00574 |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 327.808 g/mol |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | Oral-4 hours |
| Excretion | {{{excretion}}} |
| Pregnancy category | |
| Legal status | |
| Routes of administration | |
Loxapine (sold as Loxapac®, Loxitane®) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. It is a member of the dibenzodiazepine family and structurally related to clozapine. Several researchers have argued that Loxapine may behave as an atypical antipsychotic (PMID 10340686).
Loxapine may be metabolized by N-demethylation to amoxapine, a tetracyclic antidepressant (PMID 1860915).
Side effects
Side effects include tardive dyskinesia, neuroleptic malignant syndrome, extrapyramidal side effects, tremor and sedation.
Psycholeptics: antipsychotics (N05A)
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|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Zotepine) |
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