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Loxapine

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[[Image:|150px|Loxapine chemical structure]]
Loxapine


IUPAC name
CAS number
1977-10-2
ATC code

N05AH01

PubChem
3964
DrugBank
APRD00574
Chemical formula {{{chemical_formula}}}
Molecular weight 327.808 g/mol
Bioavailability
Metabolism
Elimination half-life Oral-4 hours
Excretion {{{excretion}}}
Pregnancy category
Legal status
Routes of administration

Loxapine (sold as Loxapac®, Loxitane®) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. It is a member of the dibenzodiazepine family and structurally related to clozapine. Several researchers have argued that Loxapine may behave as an atypical antipsychotic (PMID 10340686).

Loxapine may be metabolized by N-demethylation to amoxapine, a tetracyclic antidepressant (PMID 1860915).

Side effects

Side effects include tardive dyskinesia, neuroleptic malignant syndrome, extrapyramidal side effects, tremor and sedation.


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