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Longitudinal callosal fascicles (or Probst bundles) are abnormal collections of brain cells characteristic of patients with Agenesis of the corpus callosum. Failure of the neurons that normally make up the corpus callosum to cross the midline results in anomalous collection of these cells in both hemispheres. Longitudinal callosal fascicles were originally described by Moriz Probst in 1901 by gross anatomical observation.[1] More recently, these anomalies are detected by Magnetic Resonance Imaging [2] or Diffusion Tensor Imaging.[3]


  1. Probst, M. (1901), "Über den Bau des vollständing balkenlosen Großhirns", Arch Psychiatr 34: 709–786 
  2. {{{author}}}, Anomalies of the corpus callosum: correlation with further anomalies of the brain., [[{{{publisher}}}|{{{publisher}}}]], [[{{{date}}}|{{{date}}}]].
  3. (Jan 2004). Diffusion tensor MR imaging visualizes the altered hemispheric fiber connection in callosal dysgenesis.. AJNR Am J Neuroradiol 25 (1): 25–8.
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